How the gut, liver and microbiota interact in health and disease

LIMR GHAM Antimicrobial Resistance 1400x700

Oesophageal High Resolution Manometry-idiopathic pulmonary fibrosis (IPF)

Manometry Pics

C. difficile encased in a multispecies biofilm

c.difficile biofilm

How the gut, liver and microbiota interact in health and disease

LIMR GHAM Hepatology 1400x700
Scroll down

LIMR Division of Gastroenterology, Hepatology and Antimicrobial Resistance

Welcome to the Division of Gastroenterology, Hepatology and Antimicrobial Resistance (GHAM)


Head of Division: Dr Ian Rowe

Deputy Head of division: Dr Caroline Chilton


The Gastroenterology, Hepatology and Antimicrobial Resistance (GHAM) division brings together complementary strengths in gastrointestinal, liver, and antimicrobial research to address pressing clinical challenges and improve patient outcomes. Supported by NIHR infrastructure awards, including the Biomedical Research Centre and HealthTech Research Centre, GHAM provides a platform for cutting-edge science, fostering innovation, collaboration and the development of future academic leaders.

Our research spans fundamental biology, translational studies, and patient-centred clinical investigations. By integrating expertise across gastroenterology, hepatology, and antimicrobial resistance, we explore how the gut, liver and microbiota interact to influence health, resilience and treatment strategies, aiming to understand disease mechanisms, develop innovative diagnostics and therapies, and evaluate interventions at both individual and population levels to improve patient outcomes.

Key Focus Areas:

  • Gastroenterology: Advancing early detection and prevention of gastrointestinal disease, including colorectal cancer; improving understanding of gut-brain interactions and gastrointestinal symptom management; exploring microbiome-diet interactions; and developing targeted therapies for conditions such as IBS.
  • Hepatology: Addressing patient-relevant liver disease challenges, including non-alcoholic fatty liver disease (NAFLD) and cirrhosis, with a focus on early diagnosis, risk stratification, and prevention of complications.
  • Antimicrobial Resistance (AMR): Evaluating new treatments and diagnostics for healthcare-associated infections; conducting large-scale surveillance of resistance patterns; and investigating the interplay between gut microbiota, nutrients, and antimicrobials to identify biomarkers and therapeutic strategies.

Across all areas, GHAM researchers collaborate closely with Leeds Teaching Hospitals NHS Trust, the University of Leeds, and patient and public engagement groups. This integrated approach ensures our research is translational, patient-focused, and positioned to influence clinical practice, public health, and policy.


 

The Intelligence Layer: Who Drives the Science

Our work is powered by a diverse and interconnected network of researchers, analysts, and clinicians. Across disciplines and career stages, each contributes unique expertise to generate, interpret, and translate data into insight on antimicrobial resistance. 

Prof Wilcox (Leeds, NHS) leads national AMR efforts. His research covers C. difficile, diagnostics, antibiotic resistance, gut microbiome, and antimicrobial development.

More on Prof. Mark Wilcox

Prof Hull is a clinician scientist focused on colorectal cancer prevention, integrating molecular biology, nutrition, and clinical trials to develop chemoprevention and risk-reduction strategies.

More on Prof. Mark Hull

Prof Houghton focuses on gut–brain disorders like IBS and connections between gastrointestinal dysfunction and diseases such as respiratory conditions.

More on Prof. Lesley Houghton

Prof. Ford studies the epidemiology and treatment of disorders of gut-brain interaction, such as irritable bowel syndrome and functional dyspepsia, using randomised trials and meta-analysis.

More on Prof. Alex Ford

Dr Sandoe focuses on antimicrobial stewardship and prescribing, with expertise in infective endocarditis, healthcare-associated infections, and antimicrobial resistance.

More on Dr Jonathan Sandoe

Dr Kirby focuses on complex intra-abdominal infections, surgical antibiotic prophylaxis, and healthcare-associated infections, integrating antibiotic pharmacology with narrative-based approaches.

More on Dr Andrew Kirby

Dr Rowe is a clinical hepatologist focusing on liver disease outcomes, risk stratification, and early detection of complications, integrating epidemiology and clinical trials to improve patient care.

More on Dr Ian Rowe

Dr Chilton is specialising in healthcare-associated infections, antimicrobial resistance, and gut microbiota, using in vitro models to study antibiotic–microbiome interactions and C. difficile.

More on Dr Caroline Chilton

Dr Freeman is a Clinical microbiologist specialising in Clostridioides difficile, antimicrobial-mediated dysbiosis, AMR, and diagnostics; established the human gut model of CDI at Leeds.

More on Dr Jane Freeman

Dr Mitra integrates microbiome, dietary, and environmental datasets to uncover how antimicrobial resistance (AMR) emerges across systems, focusing on global health and underrepresented populations.

More on Dr Suparna Mitra

Dr Moura decodes gut microbiome dynamics and antimicrobial resistance using advanced in vitro models to understand pathogen behaviour, antibiotic impact, and therapeutic interventions.

More on Dr Ines Moura

Dr Rooney is a Clinical microbiologist bridging microbiome research and patient care, focusing on AMR, autoimmunity, and translating multi-omics insights into diagnostics and practice.

More on Dr Christopher Rooney