Professor Mark Wilcox


Professor Wilcox is a Consultant / Head of Microbiology Research & Development / and Infection Lead of the Leeds NIHR Diagnostic Technologies Medical Technology and In Vitro Diagnostic Co-operative at Leeds Teaching Hospitals NHS Trust;

Professor of Medical Microbiology, Sir Edward Brotherton Chair of Bacteriology, at the University of Leeds;

Lead on C. difficile infection for Public Health England; &

Medical Advisor to the National Infection Prevention & Control Lead at NHS Improvement.

He has formerly been the Director of Infection Prevention (4 years), Infection Control Doctor (8 years), Clinical Director of Pathology (6 years) and Head of Microbiology (15 years) at LTHT.

MW is Chair of PHE’s Rapid Review Panel (reviews the utility of infection prevention & control products for the NHS), Deputy Chair of the UK Department of Health’s Antimicrobial Resistance and Healthcare Associated Infection (ARHAI) Committee and is a member of the PHE’s Programme Board on Healthcare Associated Infection & Antimicrobial Resistance.  He is a member of the Medical Research Council’s Infections and Immunity Board, and the Scientific Advisory Board for the EU Innovative Medicines Initiative’s COMBACTE-NET consortium.  From 2017, he has been seconded one day per week to NHS Improvement to support the delivery of the new national target to reduce healthcare associated Gram-negative blood stream infections in England.

He is an advisor to the Department of Health in England on healthcare associated infections (HCAIs), the UK EPIC/NICE projects, the Health Technology Assessment (HTA) programme on Healthcare Associated Infection, the Wellcome Trust and CARB-X panel on novel antimicrobials, and the European Centre for Disease Control.  He is a member of UK, European and US working groups on C. difficile infection, and is on the Editorial Boards of Lancet Gastroenterology & Hepatology, Journal of Hospital Infection and Infectious Diseases in Clinical Practice.  He has provided clinical advice as part of the FDA/EMA submissions for the approval of several novel antimicrobial agents, 1998-2016.

Professor Wilcox heads a Healthcare Associated Infection research team at the University of Leeds (, comprising ~30 doctors, scientists and nurses; projects include multiple aspects of Clostridium difficile infection, diagnostics, antibiotic resistance and the gut microbiome, staphylococcal infection, and the clinical development of new antimicrobial agents.  He has a track record of translational research, including providing the basis of clinical advice to the NHS.  He has been the Principal/UK Investigator for 15 clinical trials of new anti-infective drugs, 1999-2018, has carried out multiple NIHR portfolio studies on healthcare associated infection topics, and is currently supplying central laboratory services for several clinical trials of antimicrobial agents.  He has authored >470 papers and published a number of books and chapters.  He is co-editor of Antimicrobial Chemotherapy (5th/6th/7th Eds, 2007/12/15).


  • Sir Edward Brotherton Chair of Bacteriology; Head of HealthCare Associated Infection Research Group.
  • Consultant; Head of Microbiology Research & Development; & Infection Lead of Leeds NIHR MIC, LTHT.
  • Lead on C. difficile infection, Public Health England, Medical Advisor, NHS Improvement.

Research interests

Multiple aspects of Clostridium difficile infection, diagnostics, antibiotic resistance and the gut microbiome, staphylococcal infection, and the clinical development of new antimicrobial agents. 


  • B Med Sci
  • BM, BS
  • MD
  • FRCPath

Professional memberships

  • Healhcare Infection Society
  • British Society of Antimicrobial Chemotherapy
  • European Society of Clinical Microbiology & Infectious Diseases
  • Infectious Disease Society of America
  • American Society for Microbiology

Research groups and institutes

  • Leeds Institute of Medical Research at St James's

Current postgraduate researchers

<h4>Postgraduate research opportunities</h4> <p>We welcome enquiries from motivated and qualified applicants from all around the world who are interested in PhD study. Our <a href="">research opportunities</a> allow you to search for projects and scholarships.</p>
    <li><a href="//">Clinical Gastroenterology: Investigation of Fidaxomicin Resistance Mechanisms in Clostridium difficile </a></li> <li><a href="//">Clinical Gastroenterology: The regulation of GDH expression in Clostridioides difficile </a></li>