Genes that hold the clues to bladder cancer and its treatment

Scientists have discovered the ‘genetic signatures’ of the most common form of bladder cancer – and it could open up the possibility of better-targeted treatment, according to research.

The study looked at non-invasive bladder cancer tumours which form in the lining of the bladder and have not spread to the bladder muscle. 

According to the NHS, there are 10,000 new cases of bladder cancer diagnosed in the UK every year, more than half of which are non-invasive.

The researchers from the University of Leeds, who were funded by Yorkshire Cancer Research, found that there are two genetic variants or subtypes of these tumours.

At the moment, all patients with non-invasive bladder cancer are treated similarly but scientists believe by understanding the genetic mutations involved in each of the subtypes, more targeted therapies can be offered.

Lead investigator Professor Margaret Knowles, from the Leeds Institute of Cancer and Pathology, said: “We have already identified a vulnerability in the cancer cells of one of the genetic subtypes. Our aim is to see if we can develop an experimental compound that could exploit this vulnerability, with the eventual aim of developing a drug that would kill the cancer cells.

“Although these tumours are not usually life-threatening, they frequently recur and patients require long-term invasive monitoring and repeated surgery.

“Our improved ability to identify these specific molecular features of individual tumours should allow a more personalised approach to therapy and disease management in future.”

The research found that many of the genetic mutations in these tumours disrupt so-called tumour suppressor genes, which normally act to prevent cancers.

The genetic flaws that contribute to the development of the tumours are not inherited but accumulate throughout life, largely through exposure to environmental factors, including cigarette smoking.

Dr Kathryn Scott, Chief Executive at Yorkshire Cancer Research, commenting on the research findings, said: “This is a fantastic discovery that could change the way we treat bladder cancer. Personalised treatment is a particularly exciting area of cancer research.