Dr Ane Appelt

Dr Ane Appelt

Profile

I am a clinical radiotherapy researcher, with a background in medical physics and oncology. I joined the university in 2016 and currently holds a Yorkshire Cancer Research Fellowship.

I received my BSc in physics from the University of Southern Denmark in 2006 and my MSc in theoretical particle physics from the University of Durham in 2009, before completing a PhD in oncology from the University of Southern Denmark. Subsequently, I have held a postdoctoral position at Rigshospitalet, University of Copenhagen, with several long stays as visiting researcher at the University of Wisconsin, Madison, and the MD Anderson Cancer Center in Houston, Texas.

I maintain links with the University of Southern Denmark, where I hold an honorary associate Professorship in Radiobiology.

Research interests

I work on optimizing and individualizing radiotherapy, with a focus on pelvic radiotherapy outcomes and model-based predictions of late treatment toxicity.

My research centres around clinical trials and quantitative radiotherapy studies. I feel strongly about conducting research that is relevant to and can be translated into clinical practice, and I am thus closely involved in several clinical trials of novel radiotherapy treatment strategies. I hold an honorary clinical position with the Department of Medical Physics at St James’s University Hospital, and divide my time between offices in Clinical Oncology and Medical Physics in the Bexley Wing, SJUH.

My quantitative work in bioeffect modelling focus on normal tissue dose-volume effects, development of tumour response models, and estimation of effects of clinical risk factors. This has included image-based dose-response analysis and advanced survival analyses; focusing on outcomes after radiotherapy and optimization of complex models.

I have an interest in improving radiotherapy dose planning and delivery techniques, e.g. for optimal delivering for novel indications and individualization of treatment. I have published on breath hold methods for optimal heart sparing, image-guided brachytherapy, and rectal cancer tumour boost techniques. 

My clinical interests are wide-ranging, but centred on innovative rectal cancer treatment strategies, such as definitive chemoradiotherapy and non-surgical management, and strategies for integration of patient-reported outcomes and shared decision-making methodologies into treatment optimization.

Qualifications

  • Clinical Scientist, HCPC
  • PhD in Oncology
  • MSc in Elementary Particle Theory
  • BSc in Physics

Professional memberships

  • European Society for Radiotherapy & Oncology (ESTRO)
  • UK Clinical and Translational Radiotherapy Research Working Group (CTRad)

Research groups and institutes

  • Leeds Institute of Medical Research at St James's
  • Clinical Cancer Research Group
  • The Radiotherapy Research Group
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