Dr Ane Appelt
- Position: Associate Professor
- Areas of expertise: Radiotherapy; medical physics; clinical oncology; clinical trials; prediction modelling; outcome modelling; radiobiology; rectal cancer; anal cancer; lung cancer; pelvic radiation toxicity
- Email: A.L.Appelt@leeds.ac.uk
- Phone: +44(0)750 244 7087
- Location: Radiotherapy Research Office, Level 4 Bexley Wing, St James’s University Hospital
- Website: Twitter | LinkedIn | Googlescholar | ORCID
Profile
I am a clinical radiotherapy researcher, with a background in medical physics and oncology. I joined the university in 2016 and currently hold a Yorkshire Cancer Research Fellowship.
I received my BSc in physics from the University of Southern Denmark in 2006 and my MSc in theoretical particle physics from the University of Durham in 2009, before completing a PhD in oncology from the University of Southern Denmark. Subsequently, I have held a postdoctoral position at Rigshospitalet, University of Copenhagen, with several long stays as visiting researcher at the University of Wisconsin, Madison, and the MD Anderson Cancer Center in Houston, Texas.
I maintain links with the University of Southern Denmark, where I hold an honorary associate Professorship in Radiobiology.
Research interests
I work on optimizing and individualizing radiotherapy, with a focus on pelvic radiotherapy outcomes and model-based predictions of late treatment toxicity.
My research centres around clinical trials and quantitative radiotherapy studies. I feel strongly about conducting research that is relevant to and can be translated into clinical practice; and I am closely involved in several clinical trials of novel radiotherapy treatment strategies. I hold an honorary clinical position with the Department of Medical Physics at St James’s University Hospital, and spend a third of my time working in the radiotherapy department.
My clinical and academic expertice includes
- Quantitative radiation oncology - normal tissue and tumour dose-response, imaging-based response assessment, deep learning methodology, and advanced survival analysis
- Innovative radiotherapy treatment strategies, in particular for lung and lower GI cancer
- Improving re-irradiation through novel approaches to dose accumulation and treatment optimisation
- Reforming and standardising rectal cancer radiotherapy
- Clinical trial design and delivery
Qualifications
- Clinical Scientist, HCPC
- PhD in Oncology
- MSc in Elementary Particle Theory
- BSc in Physics
Professional memberships
- European Society for Radiotherapy & Oncology (ESTRO)
- UK Clinical and Translational Radiotherapy Research Working Group (CTRad)
Research groups and institutes
- Leeds Institute of Medical Research at St James's
- Clinical Cancer Research Group
- The Radiotherapy Research Group