Dr Ane Appelt

Dr Ane Appelt


I am a clinical radiotherapy researcher, with a background in medical physics and oncology. I joined the university in 2016 and currently hold a Yorkshire Cancer Research Fellowship.

I received my BSc in physics from the University of Southern Denmark in 2006 and my MSc in theoretical particle physics from the University of Durham in 2009, before completing a PhD in oncology from the University of Southern Denmark. Subsequently, I have held a postdoctoral position at Rigshospitalet, University of Copenhagen, with several long stays as visiting researcher at the University of Wisconsin, Madison, and the MD Anderson Cancer Center in Houston, Texas.

I maintain links with the University of Southern Denmark, where I hold an honorary associate Professorship in Radiobiology.

Research interests

I work on optimizing and individualizing radiotherapy, with a focus on pelvic radiotherapy outcomes and model-based predictions of late treatment toxicity.

My research centres around clinical trials and quantitative radiotherapy studies. I feel strongly about conducting research that is relevant to and can be translated into clinical practice; and I am closely involved in several clinical trials of novel radiotherapy treatment strategies. I hold an honorary clinical position with the Department of Medical Physics at St James’s University Hospital, and spend a third of my time working in the radiotherapy department.

My clinical and academic expertice includes

  • Quantitative radiation oncology - normal tissue and tumour dose-response, imaging-based response assessment, deep learning methodology, and advanced survival analysis
  • Innovative radiotherapy treatment strategies, in particular for lung and lower GI cancer
  • Improving re-irradiation through novel approaches to dose accumulation and treatment optimisation
  • Reforming and standardising rectal cancer radiotherapy
  • Clinical trial design and delivery


  • Clinical Scientist, HCPC
  • PhD in Oncology
  • MSc in Elementary Particle Theory
  • BSc in Physics

Professional memberships

  • European Society for Radiotherapy & Oncology (ESTRO)
  • UK Clinical and Translational Radiotherapy Research Working Group (CTRad)

Research groups and institutes

  • Leeds Institute of Medical Research at St James's
  • Clinical Cancer Research Group
  • The Radiotherapy Research Group
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