Dr Andrew MN Walker
- Position: NIHR Academic Clinical Lecturer in Cardiology
- Areas of expertise: Cardiology; Cardiovascular Medicine; Vascular Repair and Regeneration; Diabetes; Insulin Resistance; Aging; Angiogenesis; Sepsis; Heart failure
- Email: A.M.N.Walker@leeds.ac.uk
- Location: LIGHT Laboratories
- Website: Twitter | ORCID
I graduated from the University of Sheffield in 2009 with BMedSci (1st Class Hons) and MBChB degrees. I was awarded membership of the Royal College of Physicians of London in 2012, before joining the University of Leeds in 2013, initially with a British Heart Foundation Research Scholarship. I was funded through a British Heart Foundation Clinical Research Training Fellowship between 2014 and 2017, following which I was awarded a PhD for my research project titled: Exploring the Role of the Insulin and Insulin-Like Growth Factor Receptors in Vascular Regeneration and Aging.
In 2017 I was appointed as a NIHR Academic Clinical Fellow in Cardiology based in the Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM) and Bradford Royal Infirmary.
Since March 2019 I have continued my research work in LICAMM, with clinical responsibilities at Leeds General Infirmary as part of my appointment as a NIHR Academic Clinical Lecturer in Cardiology,
- Deputy Action Group Lead for Student Education
- Personal Tutor for iBSc Cardiovascular Medicine
- Lecturer on MBChB, iBSc in Cardiovascular Medicine and Cardiac Physiology Programmes
My research interests include preclinical work investigating the role of the Insulin and Insulin-Like Growth Factor receptors in vascular regeneration and ageing. I also conduct clinical research in the field of heart failure, with a particular interest in factors which influence the prognosis of patients with insulin resistance and diabetes.
Prevalence and Predictors of Sepsis Death in Patients With Chronic Heart Failure and Reduced Left Ventricular Ejection Fraction. Walker AMN et al. JAHA 2018;7:e009684 epub ahead of print: https://www.ahajournals.org/doi/10.1161/JAHA.118.009684.
Ischemic Heart Disease Modifies the Association of Atrial Fibrillation With Mortality in Heart Failure With Reduced Ejection Fraction. Mercer BN et al. JAHA 2018; 7:e009770 epub ahead of print: https://www.ahajournals.org/doi/10.1161/JAHA.118.009770.
Endothelial Insulin Receptor Restoration Rescues Vascular Function in Male Insulin Receptor Haploinsufficient Mice. Sengupta A et al. Endocrinology 2018; 159(8): 2917-25.
Socioeconomic deprivation and mode-specific outcomes in patients with chronic heart failure. Witte KK et al. Heart 2018; 104(12): 993-8.
Mortality Reduction Associated With β-Adrenoceptor Inhibition in Chronic Heart Failure Is Greater in Patients With Diabetes. Witte KK et al. Diabetes Care. 2018 Jan;41(1):136-142. doi: 10.2337/dc17-1406. Epub 2017 Oct 5. PMID: 28982651.
Endothelial SHIP2 Suppresses Nox2 NADPH Oxidase-Dependent Vascular Oxidative Stress, Endothelial Dysfunction, and Systemic Insulin Resistance. Watt NT et al. Diabetes. 2017 Nov;66(11):2808-2821. doi: 10.2337/db17-0062. Epub 2017 Aug 22. PMID: 28830894.
Selective Enhancement of Insulin Sensitivity in the Endothelium In Vivo Reveals a Novel Proatherosclerotic Signaling Loop. Viswambharan H et al. Circulation Research. 2017 Mar 3;120(5):784-798. doi: 10.1161/CIRCRESAHA.116.309678. Epub 2016 Dec 5. PMID: 27920123. Accompanying Editorial (Siragusa M, Fisslthaler B. Insulin Keeps PYK-ing on eNOS: Enhanced Insulin Receptor Signaling Induces Endothelial Dysfunction. Circulation research 2017; 120(5): 748-50.)
Diabetes mellitus is associated with adverse structural and functional cardiac remodelling in chronic heart failure with reduced ejection fraction. Walker AM et al. Diabetes and Vascular Disease Research. 2016 Sep;13(5):331-40. doi: 10.1177/1479164116653342. Epub 2016 Jun 22. PMID: 27334485. .
Performance of 2014 NICE defibrillator implantation guidelines in heart failure risk stratification. Cubbon RM et al. Heart. 2016 May 15;102(10):735-40. PMID:26857212. Accompanying Editorial (Cowie MR. Updated guidance from NICE on implantable defibrillators: does it work in real life? Heart 2016; 102(10): 731-2.).
Ambulatory heart rate range predicts mode-specific mortality and hospitalisation in chronic heart failure. Cubbon RM et al. Heart. 2016 Feb;102(3):223-9. PMID:26674986.
Sudden cardiac death in patients with diabetes mellitus and chronic heart failure Diabetes and Vascular Disease Research. 2015 Jul;12(4):228-33. Walker AMN et al. PMID:25861812 Review.
Restoring Akt1 activity in outgrowth endothelial cells from South Asian men rescues vascular reparative potential. Cubbon RM et al. Stem Cells. 2014 Oct;32(10):2714-23. PMID:24916783.
Contemporary treatment strategies for Type 2 diabetes-related macrovascular disease. Walker AMN et al. Expert Review of Endocrinology & Metabolism. Vol. 9 , Iss. 6,2014.
A 16 year old boy with chest pain. Walker AMN et al. British Medical Journal. 2014 Oct 15;349:g6172. PMID:25319730.
Cardiology day case unit: the way to manage chronic cardiovascular conditions cost-effectively in future. Walker AMN et al. Clinical Medicine. 2012 Aug;12(4):398-9. PMID: 25319730.
- BMedSci (Hons)
- MRCP (London)
- British Cardiovascular Society
- American Heart Association
- Member of the Royal College of Physicians of London
- Fellow of the Higher Education Academy (Advance HE)
I lecture on the MBChB course as part of the Core Body Systems Module
I lecture on the Cardiac Physiology degree programme
I am a Lecturer and personal tutor for Intercalated BSc Students in Cardiovascular Medicine
I provide ward and clinic-based teaching to MBChB students on clinical attachment
I teach Core Medical Trainees in the Yorkshire and the Humber region on a range of topics within Cardiology along with skills in critical analysis and the interpretation of evidence and guidelines.
I planned and delivered the Leeds Learning to Teach Programme, providing a foundation in pedagogic theory alongside practical experience in a range of teaching settings for undergraduates on the MBChB programme.
In June 2019 I was appointed Deputy Action Group Lead for Student Education in LICAMM
Research groups and institutes
- Leeds Institute of Cardiovascular and Metabolic Medicine
- Discovery and Translational Science