Dr Andrew MN Walker
- Position: NIHR Academic Clinical Lecturer in Cardiology
- Areas of expertise: Cardiology; Cardiovascular Medicine; Vascular Repair and Regeneration; Diabetes; Insulin Resistance; Aging; Angiogenesis; Sepsis; Heart failure
- Email: A.M.N.Walker@leeds.ac.uk
- Location: LIGHT Laboratories
- Website: Twitter | ORCID
Profile
I graduated from the University of Sheffield in 2009 with BMedSci (1st Class Hons) and MBChB degrees. I was awarded membership of the Royal College of Physicians of London in 2012, before joining the University of Leeds in 2013, initially with a British Heart Foundation Research Scholarship. I was funded through a British Heart Foundation Clinical Research Training Fellowship between 2014 and 2017, following which I was awarded a PhD for my research project titled: Exploring the Role of the Insulin and Insulin-Like Growth Factor Receptors in Vascular Regeneration and Aging.
In 2017 I was appointed as a NIHR Academic Clinical Fellow in Cardiology based in the Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM) and Bradford Royal Infirmary.
Since March 2019 I have continued my research work in LICAMM, with clinical responsibilities at Leeds General Infirmary as part of my appointment as a NIHR Academic Clinical Lecturer in Cardiology,
Responsibilities
- Deputy Action Group Lead for Student Education
- Personal Tutor for iBSc Cardiovascular Medicine
- Lecturer on MBChB, iBSc in Cardiovascular Medicine and Cardiac Physiology Programmes
Research interests
My research interests include preclinical work investigating the role of the Insulin and Insulin-Like Growth Factor receptors in vascular regeneration and ageing. I also conduct clinical research in the field of heart failure, with a particular interest in factors which influence the prognosis of patients with insulin resistance and diabetes.
Recent Publications:
Prevalence and Predictors of Sepsis Death in Patients With Chronic Heart Failure and Reduced Left Ventricular Ejection Fraction. Walker AMN et al. JAHA 2018;7:e009684 epub ahead of print: https://www.ahajournals.org/doi/10.1161/JAHA.118.009684.
Ischemic Heart Disease Modifies the Association of Atrial Fibrillation With Mortality in Heart Failure With Reduced Ejection Fraction. Mercer BN et al. JAHA 2018; 7:e009770 epub ahead of print: https://www.ahajournals.org/doi/10.1161/JAHA.118.009770.
Endothelial Insulin Receptor Restoration Rescues Vascular Function in Male Insulin Receptor Haploinsufficient Mice. Sengupta A et al. Endocrinology 2018; 159(8): 2917-25.
Socioeconomic deprivation and mode-specific outcomes in patients with chronic heart failure. Witte KK et al. Heart 2018; 104(12): 993-8.
Mortality Reduction Associated With β-Adrenoceptor Inhibition in Chronic Heart Failure Is Greater in Patients With Diabetes. Witte KK et al. Diabetes Care. 2018 Jan;41(1):136-142. doi: 10.2337/dc17-1406. Epub 2017 Oct 5. PMID: 28982651.
Endothelial SHIP2 Suppresses Nox2 NADPH Oxidase-Dependent Vascular Oxidative Stress, Endothelial Dysfunction, and Systemic Insulin Resistance. Watt NT et al. Diabetes. 2017 Nov;66(11):2808-2821. doi: 10.2337/db17-0062. Epub 2017 Aug 22. PMID: 28830894.
Selective Enhancement of Insulin Sensitivity in the Endothelium In Vivo Reveals a Novel Proatherosclerotic Signaling Loop. Viswambharan H et al. Circulation Research. 2017 Mar 3;120(5):784-798. doi: 10.1161/CIRCRESAHA.116.309678. Epub 2016 Dec 5. PMID: 27920123. Accompanying Editorial (Siragusa M, Fisslthaler B. Insulin Keeps PYK-ing on eNOS: Enhanced Insulin Receptor Signaling Induces Endothelial Dysfunction. Circulation research 2017; 120(5): 748-50.)
Diabetes mellitus is associated with adverse structural and functional cardiac remodelling in chronic heart failure with reduced ejection fraction. Walker AM et al. Diabetes and Vascular Disease Research. 2016 Sep;13(5):331-40. doi: 10.1177/1479164116653342. Epub 2016 Jun 22. PMID: 27334485. .
Performance of 2014 NICE defibrillator implantation guidelines in heart failure risk stratification. Cubbon RM et al. Heart. 2016 May 15;102(10):735-40. PMID:26857212. Accompanying Editorial (Cowie MR. Updated guidance from NICE on implantable defibrillators: does it work in real life? Heart 2016; 102(10): 731-2.).
Ambulatory heart rate range predicts mode-specific mortality and hospitalisation in chronic heart failure. Cubbon RM et al. Heart. 2016 Feb;102(3):223-9. PMID:26674986.
Sudden cardiac death in patients with diabetes mellitus and chronic heart failure Diabetes and Vascular Disease Research. 2015 Jul;12(4):228-33. Walker AMN et al. PMID:25861812 Review.
Restoring Akt1 activity in outgrowth endothelial cells from South Asian men rescues vascular reparative potential. Cubbon RM et al. Stem Cells. 2014 Oct;32(10):2714-23. PMID:24916783.
Contemporary treatment strategies for Type 2 diabetes-related macrovascular disease. Walker AMN et al. Expert Review of Endocrinology & Metabolism. Vol. 9 , Iss. 6,2014.
A 16 year old boy with chest pain. Walker AMN et al. British Medical Journal. 2014 Oct 15;349:g6172. PMID:25319730.
Cardiology day case unit: the way to manage chronic cardiovascular conditions cost-effectively in future. Walker AMN et al. Clinical Medicine. 2012 Aug;12(4):398-9. PMID: 25319730.
Qualifications
- BMedSci (Hons)
- MBChB
- MRCP (London)
- PhD
- FHEA
Professional memberships
- British Cardiovascular Society
- American Heart Association
- Member of the Royal College of Physicians of London
- Fellow of the Higher Education Academy (Advance HE)
Student education
I lecture on the MBChB course as part of the Core Body Systems Module
I lecture on the Cardiac Physiology degree programme
I am a Lecturer and personal tutor for Intercalated BSc Students in Cardiovascular Medicine
I provide ward and clinic-based teaching to MBChB students on clinical attachment
I teach Core Medical Trainees in the Yorkshire and the Humber region on a range of topics within Cardiology along with skills in critical analysis and the interpretation of evidence and guidelines.
I planned and delivered the Leeds Learning to Teach Programme, providing a foundation in pedagogic theory alongside practical experience in a range of teaching settings for undergraduates on the MBChB programme.
In June 2019 I was appointed Deputy Action Group Lead for Student Education in LICAMM
Research groups and institutes
- Leeds Institute of Cardiovascular and Metabolic Medicine
- Discovery and Translational Science