Dr Andrew MN Walker
- Position: Lecturer/Honorary Consultant Cardiologist
- Areas of expertise: Curriculum Development; Technology Enhanced Learning; Peer Learning; Cardiology; Vascular Repair and Regeneration; Diabetes; Insulin Resistance; Aging; Angiogenesis; Sepsis; Heart Failure; Coronary CT
- Email: A.M.N.Walker@leeds.ac.uk
- Location: 6.35 LIGHT Laboratories
- Website: | Twitter | ORCID
I graduated from the University of Sheffield in 2009 with BMedSci (1st Class Hons) and MBChB degrees. I was awarded membership of the Royal College of Physicians of London in 2012, before joining the University of Leeds in 2013, initially with a British Heart Foundation Research Scholarship. I was funded through a British Heart Foundation Clinical Research Training Fellowship between 2014 and 2017, following which I was awarded a PhD for my research project titled: Exploring the Role of the Insulin and Insulin-Like Growth Factor Receptors in Vascular Regeneration and Aging.
In 2017 I was appointed as a NIHR Academic Clinical Fellow in Cardiology based in the Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM) and Bradford Royal Infirmary.
Between March 2019 and March 2023 I continued my research work in LICAMM, with clinical responsibilities at Leeds General Infirmary as part of my appointment as a NIHR Academic Clinical Lecturer in Cardiology.
In March 2023 I was appointed Lecturer (Teaching and Scholarship) and Honorary Consultant Cardiologist in LIME & Leeds Teaching Hospitals.
I have significant teaching interests, and was awarded Fellowship of the Higher Education Academy (FHEA) in 2019. I lead the Cardiovascular Strand of Body Systems in Year 1 MBChB and was Co-Lead for IDEALS Year 2 until October 2021.
I am the Academic Lead for Training and Recognition in the School of Medicine.
In January 2022 I recieved a Leeds Institute for Teaching Excellence (LITE) Fellowship to work on a review of the MBChB curriculum:
Curriculum Redefined: A Representative Medical Curriculum to Reflect the Diverse Populations we Care for, and those we Educate. January 2022 onwards (3 year project).
- LITE Fellow - A Representative Medical Curriculum
- Cardiovascular Strand Lead, Body Systems Yearr 1
- Academic Lead for Training and Recognition SoM
My research interests include preclinical work investigating the role of the Insulin and Insulin-Like Growth Factor receptors in vascular regeneration and ageing. I also conduct clinical research in the field of heart failure, with a particular interest in factors which influence the prognosis of patients with insulin resistance and diabetes.
Diabetes mellitus and the causes of hospitalisation in people with heart failure. Malik A, Walker AMN et al. Diab Vasc Dis Res 2022. Jan-Feb 2022;19(1):14791641211073943. doi: 10.1177/14791641211073943. PMID: 35236158. https://pubmed.ncbi.nlm.nih.gov/35236158/. Contributing author.
Novel Paracrine Action of Endothelium Enhances Glucose Uptake in Muscle and Fat. Viswambharan, Walker AMN et al. Circulation Research 2021 Sep 17;129(7):720-734. doi: 10.1161/CIRCRESAHA.121.319517. Epub 2021 Aug 21. PMID: 34420367. https://pubmed.ncbi.nlm.nih.gov/34420367/.
Endothelial Insulin Receptors Promote VEGF-A Signaling via ERK1/2 and Sprouting Angiogenesis. Walker AMN et al. Endocrinology 2021 Aug 1;162(8):bqab104.doi: 10.1210/endocr/bqab104. PMID: 34037749. https://pubmed.ncbi.nlm.nih.gov/34037749/.
Diabetes, gender and deterioration in estimated glomerular filtration rate in patients with chronic heart failure: Ten-year prospective cohort study. Kearney J, Walker AMN et al. Diab Vasc Dis Res. 2021 Jan-Feb;18(1):1479164120984433. doi: 10.1177/1479164120984433. PMID: 33588611. https://journals.sagepub.com/doi/10.1177/1479164120984433?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed& Contributing author.
Association of heart failure and its comorbidities with loss of life expectancy. Drozd M, Relton SD, Walker AMN et al. Heart. 2020 Nov 5:heartjnl-2020-317833. doi: 10.1136/heartjnl-2020-317833. PMID: 33153996. https://heart.bmj.com/content/early/2020/11/05/heartjnl-2020-317833.long.
Infection-Related Hospitalization in Heart Failure With Reduced Ejection Fraction: A Prospective Observational Cohort Study. Circ Heart Fail. 2020 May;13(5):e006746. doi: 10.1161/CIRCHEARTFAILURE.119.006746. Epub 2020 May 1. http://eprints.whiterose.ac.uk/158358/.
Prevalence and Predictors of Sepsis Death in Patients With Chronic Heart Failure and Reduced Left Ventricular Ejection Fraction. Walker AMN et al. JAHA 2018;7:e009684: https://www.ahajournals.org/doi/10.1161/JAHA.118.009684.
Ischemic Heart Disease Modifies the Association of Atrial Fibrillation With Mortality in Heart Failure With Reduced Ejection Fraction. Mercer BN et al. JAHA 2018; 7:e009770: https://www.ahajournals.org/doi/10.1161/JAHA.118.009770.
Endothelial Insulin Receptor Restoration Rescues Vascular Function in Male Insulin Receptor Haploinsufficient Mice. Sengupta A et al. Endocrinology 2018; 159(8): 2917-25.
Socioeconomic deprivation and mode-specific outcomes in patients with chronic heart failure. Witte KK et al. Heart 2018; 104(12): 993-8.
Mortality Reduction Associated With β-Adrenoceptor Inhibition in Chronic Heart Failure Is Greater in Patients With Diabetes. Witte KK et al. Diabetes Care. 2018 Jan;41(1):136-142. doi: 10.2337/dc17-1406. Epub 2017 Oct 5. PMID: 28982651.
Endothelial SHIP2 Suppresses Nox2 NADPH Oxidase-Dependent Vascular Oxidative Stress, Endothelial Dysfunction, and Systemic Insulin Resistance. Watt NT et al. Diabetes. 2017 Nov;66(11):2808-2821. doi: 10.2337/db17-0062. Epub 2017 Aug 22. PMID: 28830894.
Selective Enhancement of Insulin Sensitivity in the Endothelium In Vivo Reveals a Novel Proatherosclerotic Signaling Loop. Viswambharan H et al. Circulation Research. 2017 Mar 3;120(5):784-798. doi: 10.1161/CIRCRESAHA.116.309678. Epub 2016 Dec 5. PMID: 27920123. Accompanying Editorial (Siragusa M, Fisslthaler B. Insulin Keeps PYK-ing on eNOS: Enhanced Insulin Receptor Signaling Induces Endothelial Dysfunction. Circulation research 2017; 120(5): 748-50.)
Diabetes mellitus is associated with adverse structural and functional cardiac remodelling in chronic heart failure with reduced ejection fraction. Walker AM et al. Diabetes and Vascular Disease Research. 2016 Sep;13(5):331-40. doi: 10.1177/1479164116653342. Epub 2016 Jun 22. PMID: 27334485. .
Performance of 2014 NICE defibrillator implantation guidelines in heart failure risk stratification. Cubbon RM et al. Heart. 2016 May 15;102(10):735-40. PMID:26857212. Accompanying Editorial (Cowie MR. Updated guidance from NICE on implantable defibrillators: does it work in real life? Heart 2016; 102(10): 731-2.).
Ambulatory heart rate range predicts mode-specific mortality and hospitalisation in chronic heart failure. Cubbon RM et al. Heart. 2016 Feb;102(3):223-9. PMID:26674986.
Sudden cardiac death in patients with diabetes mellitus and chronic heart failure Diabetes and Vascular Disease Research. 2015 Jul;12(4):228-33. Walker AMN et al. PMID:25861812 Review.
Restoring Akt1 activity in outgrowth endothelial cells from South Asian men rescues vascular reparative potential. Cubbon RM et al. Stem Cells. 2014 Oct;32(10):2714-23. PMID:24916783.
Contemporary treatment strategies for Type 2 diabetes-related macrovascular disease. Walker AMN et al. Expert Review of Endocrinology & Metabolism. Vol. 9 , Iss. 6,2014.
A 16 year old boy with chest pain. Walker AMN et al. British Medical Journal. 2014 Oct 15;349:g6172. PMID:25319730.
Cardiology day case unit: the way to manage chronic cardiovascular conditions cost-effectively in future. Walker AMN et al. Clinical Medicine. 2012 Aug;12(4):398-9. PMID: 25319730.
- BMedSci (Hons)
- MRCP (London)
- British Cardiovascular Society
- American Heart Association
- Member of the Royal College of Physicians of London
- Fellow of the Higher Education Academy (Advance HE)
- BSCCT - British Society for Cardiac Computed Tomography
I am a current Leeds Institute for Teaching Excellence (LITE) Fellow working on a review of the MBChB curriculum:
Curriculum Redefined: A Representative Medical Curriculum. January 2022 onwards (3 year project).
I am the Academic Lead for Training and Recognition in the School of Medicine
Research groups and institutes
- Leeds Institute of Cardiovascular and Metabolic Medicine
- Discovery and Translational Science
- Cardiac Physiology
- Multidisciplinary Cardiovascular Research Centre