Dr Piruthivi Sukumar

Dr Piruthivi Sukumar


I have studied the role of TRPC channels in metabolic diseases during my PhD with Prof David J Beech at Leeds. I went on to study insulin resistance and ROS signalling in diabetes-induced vascular dysfunction during my postdoctoral work with Prof Mark Kearney in Medical School at Leeds. Following that, I took up an Assistant Professor position at Indian Institute of Technology (IIT), Guwahati, India. During my time at IIT, I continued to look at the role of ion channels in various components of metabolic syndrome.

In 2016, I took up University Academic Fellow position at LICAMM, School of Medicine, Leeds and continued my work on ion channels and cardiometabolic disorders. Our lab has identified that activation of mechanosenstive Piezo1 channels lead to insulin release from pancreatic beta cells. Currently I am an Associate Professor in Cardiovascular Medicine.


  • Action Group Lead-International Development
  • Deputy Programme Lead-International PhD Academy

Research interests

My lab is interested in teasing out the molecular mechanism behind the development of insulin and IGF-1 resistance mediated pathologies in vascular system. We are also looking at various calcium permeable ion channels including mechanosensitive channels in cardiovascular system and their role in both physiology and diseases process.


  • MBChB
  • Masters in Medical Science and Technology
  • PhD (Patho-physiology)

Professional memberships

  • Physiological Society UK
  • American Heart Association
  • Indian Medical Association

Student education

I teach in various undergraduate and postgraduate modules in School of Medicine in MBChB and other programs. I am one of the leads for the hugely popular discovery module - Introduction to Human Disease. 

Research groups and institutes

  • Leeds Institute of Cardiovascular and Metabolic Medicine
  • Discovery and Translational Science
  • Cardiovascular
  • British Heart Foundation - Cardiovascular research
  • Multidisciplinary Cardiovascular Research Centre
<h4>Postgraduate research opportunities</h4> <p>We welcome enquiries from motivated and qualified applicants from all around the world who are interested in PhD study. Our <a href="https://phd.leeds.ac.uk">research opportunities</a> allow you to search for projects and scholarships.</p>
    <li><a href="//phd.leeds.ac.uk/project/683-cardiovascular-consequences-of-single-nuclear-polymorphisms-in-novel-mechanosensing-ion-channel-piezo1">Cardiovascular consequences of single nuclear polymorphisms in novel mechanosensing ion channel Piezo1</a></li> <li><a href="//phd.leeds.ac.uk/project/812-role-of-endothelial-mechanosensory-protein-piezo1-in-covid-19-infection-and-pathogenicity">Role of endothelial mechanosensory protein PIEZO1 in COVID-19 infection and pathogenicity</a></li>