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Professor Helen Philippou

  • Position: Professor
  • Areas of expertise: Leading drug discovery programmes; Anti-thrombotics with minimal bleeding risk; Enhancement of fibrinolytic therapy; Prevention of Bleeding in Trauma; Mechanisms of thrombosis
  • Email: H.Philippou@leeds.ac.uk
  • Phone: +44(0)113 343 7768
  • Location: Division of Cardiovascular and Diabetes Research The LIGHT Building

Profile

Understanding mechanisms of thrombosis and development of novel safer antithrombotic therapeutics.Qualifications: BSc (Hons): Biomedical Sciences, PhD: Development of Activation Markers of Blood coagulation. My research since 1992 has focused on understanding the mechanisms of thrombosis, in particular to the coagulation pathway. I am the current University Lead of the Medical Research Council Confidence in Concept (MRC CiC). In addition to generation of IP with respect to my own group's research, I am also engaging other academics to identify aspects of their own research that has commercialisation potential. Currently, I supervise 3 PhD students as Lead Supervisor and 4 as co-supervisor. Recent Projects: Wellcome Trust Seeding Drug Discovery Initiative (SDDI) £3m Development of a novel anticoagulant with minimal bleeding risk. (2015-2017).

Responsibilities

  • Principal Investigator
  • Founding Director of Lunac Therapeutics Limited
  • University Lead of MRC CiC

Research interests

Currently, my group is looking into the discovery of novel therapeutics against thrombosis that will be taken orally and will have safer bleeding profiles than other antithrombotics currently available or in development. I am also interested in understanding novel mechanisms that regulate the activity of coagulation factors, and clot formation and its stability. Overall, we have established many methodologies that enable us to investigate clot formation and its stability in vitro and in vivo. These methodologies are being used to understand the nature of protein-protein interactions and other mechanisms involved in the coagulation pathway with respect to blood clot formation and its ability to be lysed by the fibrinolytic pathway. 

Qualifications

  • BSc (Hons)
  • PhD

Professional memberships

  • Scientific Secretary of the British Society of Thrombosis and Haemostasis
  • Co-Chair of the Factor XI and the Contact System Scientific and Standardization Committee (SSC) of the International Society of Thrombosis and Haemostasis (ISTH)

Research groups and institutes

  • Leeds Institute of Cardiovascular and Metabolic Medicine
  • Discovery and Translational Science
  • British Heart Foundation - Cardiovascular research
  • Multidisciplinary Cardiovascular Research Centre
<h4>Postgraduate research opportunities</h4> <p>We welcome enquiries from motivated and qualified applicants from all around the world who are interested in PhD study. Our <a href="https://phd.leeds.ac.uk">research opportunities</a> allow you to search for projects and scholarships.</p>
Projects
    <li><a href="//phd.leeds.ac.uk/project/171-role-of-neutrophils-in-fibrin-structure-and-function:-how-do-cells,-fibrin-and-neutrophil-extracellular-traps-(nets)-integrate-in-thrombi-and-blood-cl">Role of Neutrophils in Fibrin Structure and Function: How do Cells, Fibrin and Neutrophil Extracellular Traps (NETs) Integrate in Thrombi and Blood Cl</a></li>