- Position: Associate Professor (Consultant)
- Areas of expertise: Healthcare Associated Infection; Complicated intra-abdominal infection; Surgical antibiotic prophylaxis; Oral antibiotics for urinary infection (antibiotic PK/PD), Microbiology narrative education.
- Email: A.Kirby@leeds.ac.uk
- Phone: +44(0)113 392 3929
- Location: Microbiology department Old Medical School, Leeds General Infirmary
I trained in medicine at the University of Liverpool, completing training in 2001. I then undertook an MSc in Medical and Molecular Microbiology at the University of Manchester, After medical posts in the UK, Australia and New Zealand I undertook training in medical and molecular microbiology whilst a Clinical Lecturer at the University of Liverpool. During this time i completed an MD into the diagnosis an epidemiology of norovirus infection and completed professional exams in medical microbiology, before moving to Leeds. In Leeds, I work as an Associate Clinical Professor in Microbiology and as an honorary consultant microbiologist. I am also employed by the Clinical Research Network as a speciality lead in Infection, and am a member of the grants review committee at the Healthcare Infection Society. In addition, I am the consultant chair of the National Infection Trainee Collaborative for Audit and Research.
- Microbiology lead for medical student education
Surgical infection related research
Complicated intra-abdominal infection (CABI): We have completed a UK audit of the management of CABIs and a pilot RCT of antibiotic durations for the treatment of CABIs. We intend to use this data to support a national trial into the antibiotic management of CABIs.
Core outcomes for complicated-intra-abdominal infection (CABI): Our work has identified limitations in available core outcome sets for CABIs. As antibiotics for the treatment of CABIs are one of the trials commonly performed to obtain market authorisation for an antibiotic it is important a comprehensive core outcome set is developed. We plan to apply for funding to complete this research.
Antibiotic prophylaxis for colorectal surgery. We have performed a pilot trial comparing bolus-continuous infusion of antibiotic prophylaxis in colorectal surgery. We hypothesise that antibiotic prophylaxis for colorectal surgery will be optimised with a bolus-continuous infusion targeting high serum concentrations of antibiotic throughout surgery. We intend to use our pilot data to apply for funding to complete a national trial of bolus-continuous infusion of antibiotic prophylaxis.
Antibiotic management of appendicitis: We have performed a meta-analysis related to the antibiotic management of acute appendicitis. We seek to collaborate on trials into the antibiotic management of appendicitis.
Surgical trial research-IntAct: Intraoperative Fluorescence Angiography to Prevent Colorectal Anastomotic Leak. I am a Co-investigator on a trial investigating the cause of anastomotic leak after colorectal surgery. Specifically, we are investigating if collagenase producing bacteria are detected in those patients who have anastomotic leaks.
Antibiotic pharmacology (pharmacokinetics and pharmacodynamics research)
Oral antibiotics for pyelonephritis: We have evaluated the literature and determined oral antibiotics not recommended for treatment for pyelonephritis in current guidelines have data to support their use. We have completed a pharmacokinetic/pharmacodynamic analysis of a number of oral antibiotics for the treatment of pyelonephritis. We intend to use these data to support funding applications into the pharmacokinetics of oral antibiotics for pyelonephritis, and treatment of pyelonephritis with oral antibiotics.
Accelerating Development of Infection Diagnostics for Patient Management and Reduction of Antibiotic Misuse. We collaborate on this Medical Research Council funded research project.
Skin microbiome: We have completed a research project on the impact of antibiotics on the skin microbiome. We have evidence to suggest antibiotics increase the rate of skin colonisation of Gram-negative bacteria. We intend to use this pilot data to obtain funding for future research to determine the impact of antibiotics on the skin microbiome.
Infection training and education
I am the clinical lead for the National Infection Trainee Collaborative for Audit and Research. (NITCAR). This is a national group of mainly infection trainees who perform multicentre clinical projects. To date we have performed projects into Hospital Onset Diarrhoea, Complicated-intra-abdominal infection, Hepatitis C investigation, Native Vertebral Osteomyelitis and Meningitis.
GermBugs: We are developing a narrative based education project to help with the education of the public, healthcare practitioners and medical staff. The characters called GermBugs will educate as they go adventuring in illustrated and animated formats.
Structured microbiology consultations: We intend to improve training in infection, and improve clinical practice, by developing an educational tool based on a structured microbiology consultation. We intend to develop this educational tool and determine its impact.
- MSc Medical and Molecular Microbiology
- MD Medical Microbiology
- British Infection Association
- British Society of Antimicrobial Chemotherapy
- European Society of Clinical Microbiology and Infectious Diseases
- Healthcare Infection Society
- National Infection Trainee Collaborative for Audit and Research
I am the lead for the microbiology curriculum in the undergraduate medical school. I supervise medical students on ESREP projects and MRes projects.
Research groups and institutes
- Leeds Institute of Medical Research at St James's
<li><a href="//phd.leeds.ac.uk/project/394-colo-pro:-a-clinical-trial-to-compare-cefuroxime-prophylaxis-treatment-regimes-for-the-prevention-of-infections-after-colorectal-surgery-">Colo-Pro: A clinical trial to compare cefuroxime prophylaxis treatment regimes for the prevention of infections after colorectal surgery </a></li>