Dr Antreas Kalli
- Position: University Academic Fellow
- Areas of expertise: molecular dynamics simulations; molecular modelling; membrane proteins; membrane transporters; cell signalling; mechanosensitive channels.
- Email: A.Kalli@leeds.ac.uk
- Location: 6.30 LIGHT Laboratories
- Website: Astbury Webpage | Googlescholar | Researchgate | ORCID
I joined the University of Leeds in 2016 as a tenure-track University Academic Fellow. Prior to my current position, I was a post-doctoral researcher in the Sansom group at the University of Oxford. During my postdoc, I used computational methodologies to study how signalling receptors are activated. I hold a DPhil in Structural Biology from the University of Oxford and a BSc in Physics from the University of Cyprus. My group uses multi-scale molecular dynamics simulations (i.e. coarse-grained and all-atom) and molecular modelling to simulate how proteins in cell membranes work and how they interact with their environment.
- Group Leader
Membrane proteins account for almost ~25% of all genes and they are a major drug target. We use computational approaches such as multi-scale molecular dynamics simulations and molecular modelling to provide molecular/structural and dynamic details about membrane proteins. Multi-scale simulations enable us to represent the system in different resolutions (i.e. coarse-grained and all-atom) depending on the time and length scale of interest. A key aspect of our research is that we study membrane proteins in complex model membranes that resemble the native membranes in which such proteins function. This approach enables us to examine whether the function of membrane proteins is regulated by specific lipid molecules.
Our research spans the following themes:
- Biologically important systems that are involved in the immune response. We use molecular dynamics simulations to understand the activation and function of the T-cell receptor at the molecular level. We also study how its activation is regulated by its lipid environment and by cytosolic kinases.
- Membrane transport proteins. Our studies focus on i) Band 3 and ii) members of the solute carrier (SLC) transporters. With these studies, we aim to understand how these proteins behave in cell membranes and how this helps their ability to transport molecules in and out of cell membranes.
- Ion channels. We use molecular dynamics simulations to study the Piezo1 mechanosensitive channel. Piezo1 channel is a critical mechanical sensor in endothelial cells. Our aim is to examine the activation mechanism of Piezo1 and investigate how this is regulated by small molecules and lipids.
- We develop computational approaches that allows us to study proteins and their interactions with lipid molecules faster and more efficiently.
- DPhil in Structural Biology, University of Oxford (2012)
- BSc in Physics, University of Cyprus (2008)
I teach on a variety of modules for undergraduate and postgraduate courses at the Faculty of Medicine and Health and at the Faculty of Biological Sciences. Additionally, I offer projects for undergraduate and postgraduate students. These projects focus on molecular dynamics simulations of membrane proteins. If you are interested in such projects, please get in touch to discuss project options.
Research groups and institutes
- Leeds Institute of Cardiovascular and Metabolic Medicine
- British Heart Foundation - Cardiovascular research
Current postgraduate researchers
<li><a href="//phd.leeds.ac.uk/project/240-computational-approaches-to-understanding-the-mechanosensitive-piezo1-channel-activation-mechanism.">Computational approaches to understanding the mechanosensitive Piezo1 channel activation mechanism.</a></li>
<li><a href="//phd.leeds.ac.uk/project/328-understanding-piezo1,-an-exciting-new-cardiovascular-force-sensor-associated-with-human-inherited-diseases">Understanding Piezo1, an exciting new cardiovascular force-sensor associated with human inherited diseases</a></li>
<li><a href="//phd.leeds.ac.uk/project/327-understanding-how-small-molecules-modulate-mechanosensitive-ions-channels-in-cardiovascular-health-and-disease">Understanding how small molecules modulate mechanosensitive ions channels in cardiovascular health and disease</a></li>
<li><a href="//phd.leeds.ac.uk/project/390-unique-antiviral-therapy-targeting-zika-and-related-viruses-">Unique Antiviral Therapy targeting Zika and Related Viruses </a></li>