Professor David Jayne

Profile

David is Bowel Cancer UK & RCS Engl. Professor of Surgery at the University of Leeds and Hon. Consultant Surgeon at Leeds Teaching Hospitals NHS Trust. His clinical interests include robotic and minimally invasive surgery for colorectal cancer and pelvic floor dysfunction. His research interests include the development of new surgical technologies and devices to improve outcomes in colorectal disease. In 2012 he was awarded an NIHR Research Professorship to accelerate research and implementation of new technologies into clinical practice. He is currently an NIHR Senior Investigator. He is Chief Investigator for several NIHR portfolio clinical trials. He has previously served on the EME/NIHR Prioritisation and Strategy Groups, the Doctoral Research Fellowship Committee, and the Clinician Scientist Awards Panel. He is currently a member of the NIHR Advanced Fellowship Panel and the NIHR i4i Programmes. He is Clinical Director of the NIHR MedTech Co-operative in Surgical Technologies, a national network of clinicians, academics, patient & public representatives, and commercial partners to develop novel solutions to unmet surgical need. His position as Clinical Director for the NIHT Global health Research Group affords him the opportunity to apply his expertise in the clinical translation of surgical technologies to the context of low resource countries.

Responsibilities

• Associate Dean of the St James's & Chapel Allerton Hospital Campusus
• BCUK & RCS Engl. Chair of Surgery
• Clinical Director, Global Health Research Group & Clnical Director NIHR Surgical MedTechCooperative

Research interests

Basic science

• Nanotechnology: this is focused on the development of nanoparticles for image guided surgery, to help stage disease and increase surgical accuracy. Other nanoparticle related projects include targeted delivery of anti-microbial agents to wounds and analgesic medicines to surgical fields for prolonged postoperative analgesia .
• Microfluidics: collaboration with Mech Engineering at Uni Leeds to develop microfluidics devices for rapid and efficient analysis of tumour response to therapeutics.
• Regenerative Medicine: collaboration with Engineering at Uni Leeds to develop rapid setting biological gels as carriers for omental derived regenerative cells harvested during surgery and used to stimulate healing and prevent anastomotic leak.

Preclinical research

• Surgical Technologies: several collaborations with Mech Engineering at Uni Leeds to develop devices for laparoscopic surgery.
• Steerable lasers for surgical ablative therapy in collaboration with Heriot Watt University.
• Collaboration with Uni Texas and Uni Toronto to develop an implantable, miniature LED device for intracavity photodynamic therapy to prevent/treat cancer recurrence.

Early translational research

• Several first-in-man phase I clinical trials investigating the use of fluorescent markers for image guided surgery
• Phase I/II clinical trials of novel surgical devices 
• Wearable technologies – phase I/II clinical trials evaluating the use of remote monitoring devices to detect early patient deterioration following surgery and at home monitoring to assess fitness for surgery

Late phase clinical trials

• Several NIHR portfolio clinical studies including: i) European multicentre RCT of robotic surgery for rectal cancer; ii) European multicentre RCT investigation near-infrared perfusion angiography to prevent anastomotic leak following rectal cancer surgery; iii) UK multicentre RCT evaluating a new collagen plug to treat fistula-in-ano

NIHR MedTech Co-operative in Surgical Technologies

• National network funded through NIHR to facilitate pull through of new technologies into clinical practice. The 3 clinical themes are colorectal, vascular, and hepatobiliarysurgery. The underpinning research themes are: engineering and physical sciences, pathology, clinical trials & health economics, commercialisation

Global Surgery

• NIHR funded Global Health Research Group in Surgical Technologies. Projects in Sierra Leone focusing on lower limb trauma and wounds, and in NE India focusing on gasless laparoscopic surgery

Qualifications

• BSc Anatomy
• MBBCh
• FRCS
• FRCS Part III
• MD with Distinction

Professional memberships

• British Assoc. of Surgical Oncology
• Association of Coloproctology of GB&I
• Royal College of Surgeons of England
• Society of Academic & Research Surgeons

Student education

Primary Supervisor for 6 MD & 2 PhD students, University of Leeds

Co-supervisor for 3 MD & 3 PhD students, University of Leeds

External Examiner for MD & PhD theses

Internal Examiner for MD & PhD theses, University of Leeds

External Examiner for undergraduate surgery, University College Dublin

Research groups and institutes

• Leeds Institute of Medical Research at St James's