Dr Thomas A Hughes
- Position: Associate Professor
- Areas of expertise: gene regulation; cancer; post-transcriptional regulation; breast cancer; microRNAs; transcription; cancer stroma; fibroblasts; biomarkers; molecular pathology; colorectal cancer
- Email: T.Hughes@leeds.ac.uk
- Phone: +44(0)113 343 1984
- Location: WTBB St James's University Hospital, Leeds
- Website: Researchgate | ORCID
Group Leader and Associate Professor of Cancer Biology.
Published >50 peer-reviewed papers on various aspects of cancer biology and molecular cell biology.
Highly experienced reviewer, editor, and panel member for grant/paper review, and examiner for taught courses and doctoral degrees.
Lead roles in masters level education.
The aim of my research is to increase understanding of the biology of cancers, particularly breast cancer, with a view to using these new insights to improve cancer outcomes.
Particular research strengths are the regulation of gene expression, the roles of the tumour microenvironment, and the use and identification of cancer biomarkers and targets, and investigation of novel therapies.
My work involves close collaboration with staff at the Leeds NHS Trusts, including surgeons, oncologists, radiologists, pathologists and immunologists. This underpins my research by allowing access to clinical tissue and data, and translational of findings into the clinic. I also collaborate closely with engineers and chemists on the development of nanomedicine approaches for drug delivery and novel therapeutics.
Current Hughes group: TBA (post-doc), Waleed Al Amri (PhD student), Diana Baxter (PhD student), Robyn Broad (PhD student), Stacey Jones (clinical fellow), Caroline Strachan (clinical fellow).
Researchers co-supervised by Hughes: Muna Al-Jabri (PhD student, Stead PI), Sam Hutchinson (PhD student, Thorne PI), Alex Websdale (PhD student, Thorne PI), Priscilia Lianto (PhD student, Thorne PI), Yazan Khaled (clinical research felllw, Jayne PI).
Hughes group alumni: James Thorne (post-doc with TAH, now junior group leader), Rebecca Millian-Slater (MD with TAH, now consultant pathologist), Eldo Verghese (PhD with TAH, now consultant pathologist), Vicky Cookson (post-doc with TAH, now senior post-doc Sheffield), Laura Smith (post-doc with TAH, then junior group leader).
- BA Hons
Supervisor for 13 successful doctoral students since 2008, researching basic cancer biology or translational approaches to improve cancer therapies.
Supervisor for multiple masters-level project students.
Leader and contributor to masters level teaching on molecular medicine and cancer biology.
Research groups and institutes
- Leeds Institute of Medical Research at St James's
- Genetics and genomics