Professor A M Hanby
- Position: Professor (Clinical)
- Areas of expertise: Breast cancer Pathology
- Email: A.M.Hanby@leeds.ac.uk
- Phone: +44(0)113 343 8433
I have had mixed university and NHS roles and led the LICAP Breast Cancer Morphology group. University and NHS work were intertwined: I am one of a team of 5 breast pathologists in Leeds. I dissect breast specimens, analyse their histology and initiate further investigations as required. I now support research but am focused on diagnostic work in a two day week. Other tasks include management of parts of the molecular pathology service and the interpretation of molecular pathology tests; mostly HER2 FISH, but also some of the GI tests (Whipples and K-Ras) when colleagues are away and more recently in the rollout of digital breast pathology analysis. I am particularly interested in aspects of breast cancer heterogeneity and the biology of tumour stroma.
My past achievements include
PI for the Leeds clinical hub of the CR-UK stratified medicine program, which involved the establishment of tissue and information pathways to permit molecular profiling of a range of tumour types and to deliver the results back to the clinical teams and to cancer registries.
An instigator of the CR-UK/citizen science Cell slider project which involves the public in the assessments of molecular profiles of tissue from clinical trials using web-based crowdsourcing methodologies.
Co-investigator for the Breast Cancer Campaign breast tissue bank; the first and largest UK breast bio-bank, with Leeds as the Lead centre.
I established and run the regional HER2 service based in Leeds with now in excess of 1500 tests a year and my experience has helped inform national practise
2- 3 undergraduate lectures a year;
intercalated BSc supervision,
postgraduate teaching especially in the NHSStroma, CAFS, fibroblasts, basal, TMA, morphology, HER2, DCIS, 3D, reconstruction, arrays.
Current PhD supervision
Primary Supervisor, MD “ stromal volume and breast cancer biology”.\n Co-Supervisor, PhD "Epithelial-stromal interactions in breast cancer".
Co-Supervisor, MD "The role of eIF4E in breast carcinogenesis".\n Co-Supervisor, PhD “Developing 3-D models for breast cancer”.\n Co-Supervisor, PhD “The biology of Bisphosphonates”.
Co-Supervisor, PhD "Exploring the function of ERbeta2 at different subcellular locations in breast cancer".
Co-Supervisor, MD. "Array analysis of male breast cancer".
Co-Supervisor, PhD "Identification of predictive and prognostic factors in intermediate grade colorectal cancer".
Co- supervisor, Phd "Mutation analysis in 'normal' mucosa in colon cancer patients".
Additional PhD commencing April; "miRNA 21 in breast cancer" funding has included MRC and CR-UK.
Research groups and institutes
- Leeds Institute of Medical Research at St James's
- Pathology and Tumour Biology