Professor Amanda Farrin

Professor Amanda Farrin


Amanda is Professor of Clinical Trials and Evaluation of Complex Interventions at the Clinical Trials Research Unit (CTRU) within the Leeds Institute for Clinical Trials Research.

Amanda has worked as a medical statistician for over 25 years with posts in both academia and the NHS, together with a period of statistical consultancy work in the pharmaceutical industry. During the last 20 years, I have worked in an academic clinical trial environment and joined the CTRU in 2004.

As Director of Complex Interventions Division at CTRU, I take strategic and methodological leadership for an extensive portfolio of NIHR- and charity-funded trials, studies and programmes, developing and evaluating complex health and social care interventions in NHS priority areas.  Trials include those in stroke; elderly care (frailty, delirium, dementia); mental health (particularly self-harm), diet & obesity, cancer, primary care, care homes, and end-of-life & palliative care, with a focus across all clinical areas on evaluating behaviour change interventions.  


  • Director of Complex Interventions Division

Research interests

Amanda's reseach portfolio includes multi-centre phase III trials, early phase research, such as pilots, feasibilty studies and intervention development, epidemiological studies and eveidence synthesis.  I have designed a wide range of complex randomised trials, including parallel group, cluster randomised, factorial, fractional factorial and balanced incomplete block designs, multi-arm, multi stage (MAMS), feasibility & pilot studies, and (multiple) interrupted time series.

Amanda's methodological research interests encompass a broad range of trial methodology and application of rigorous and innovative methods to complex intervention trials. I direct an active programme of methodological research investigating real-world issues encountered during the design, implementation or analysis of complex intervention evaluations.  This includes:

  • design and analysis of cluster randomised trials,
  • methodological advances in early-phase complex intervention trial designs,
  • use of routine data in the design, implementation and analysis of trials,
  • design of process evaluations, including methods for maximising, measuring and monitoring intervnetion fidelity.



  • 1992 MSc Statistics, University of Sheffield
  • 1990 BSc (Hons) Mathematics with Accounting, University of Durham

Professional memberships

  • Society for Clinical Trials

Research groups and institutes

  • Leeds Institute of Clinical Trials Research
  • Complex interventions
  • Complex Interventions Division
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