Professor Sinisa Savic

Profile

I completed my udergrauate medical tranning at Newcastle University. I gained my PhD from the University of Leeds in 2010, after which I returned to full-time clinical training in immunology which I completed in 2011. I continued to develop my research interests throughout this period and in 2012 was awarded a position of Honorary Clinical Associate Professor with the University of Leeds. 

I joined the University of Leeds as Clinical Associate Professor in October 2016. Prior to this, I held a full-time NHS post as a Consultant Immunologist based at St James’s University Hospital. I was promoted to the position of Professor of Clinical Immunology in 2023. In addition to my academic role, I continue to provide care for patients with primary immunodeficiencies, systemic autoinflammatory disorders and allergies. 

I am clinical director of the Leeds NIHR-BioResource center which provides infrastructure for ongoing recruitment of patients with rare disease into research studies, including patients with PID and SAID. I chair British Society for Immunology- Clinical Professional Network (BSI-CIPN), which is the professional body of healthcare professionals providing care for patients with primary immunological disorders.

Responsibilities

• Group Leader-Clinical and Translational immunology
• Lead Clinician for Clinical Immunology and Allergy (LTHT)

Research interests

In my clinical role I lead a regional Department of Clinical Immunology at Allergy at St James’s University Hospital and provide specialist care for patients with primary immunodeficiencies, systemic autoinflammatory disorders and allergies.
I have developed internationally recognised clinical service for care of patients with chronic urticaria, drug allergies, immunodeficiencies and autoinflammatory disorders. The clinical care of these patients is supported by active research environment. 

In my academic role I lead a research group which main objective is study of the genetic basis of rare, inborn errors of immunity such as primary immunodeficiencies (PID) and systemic autoinflammatory disorders (SAID). I have contributed and led discovery of several novel conditions. Overall, this work has contributed to our wider understanding of the physiological function of the immune system, providing key insights into the pathogenesis of more common immune-mediated conditions and of inflammatory processes. 

Other interests include:

Pathogenesis and management of Chronic spontaneous urticaria (CSU). 

Drug alleragies

Inflammatory complications and immunopathogenesis of cystic fibrosis and bronchiectasis 

Clinical trials

I have experience in conducting phase II and phase III clinical trials both as a chief (4) and as principal investigator (6). The results of these trials have been published in several journals including New England Journal of Medicine. 

Qualifications

• MBBS (Newcastle Medical School)
• MSc Immunology
• PhD
• FRCPath
• MRCP

Professional memberships

• Fellow of Royal College of Pathologist
• Member of Royal College of Physicians
• European Society for Immunodeficiencies
• British Society for Clinical Immunology and Allergy
• British Society for Immunology
• International Society of Systemic Auto-Inflammatory Diseases
• EULAR

Student education

I am a lead for the immunology component of Essential Medical Science and Clinical Pathology modules Year2 MBChB

I teach on the gastrointestinal and metabolism strand, year 1 MBChB .

Research groups and institutes

• Leeds Institute of Rheumatic and Musculoskeletal Medicine
• Immunity and inflammation
• Musculoskeletal disease