Dr Cédric Duval

Dr Cédric Duval

Profile

I have studied Physiology and Molecular Biology at undergraduate level at the University of Rennes (France), before moving to Nice to undertake a MRes in Cellular Biology and Physiology, where I spent time performing research at the University of Newcastle upon Tyne.

I followed this with a 4-year Wellcome Trust PhD programme in Cellular and Molecular Physiology, at the University of Liverpool. Two short-term postdoctoral position followed, studying the effect of H. pylori on the development of gastric cancer, both in Liverpool and Leeds.

Since  2010, I work alongside Prof Robert Ariëns, focussing on the roles of Fibrinogen and Factor XIII in the aethiology of thrombosis and thromboembolism.

I am a Committee Member of the British Society for Haemostasis and Thrombosis, Member of the School of Medicine Research Ethics Committee, and Thrombosis Review Editor for Frontiers in Cardiovascular Medicine.

Outside work, I am a keen long-distance runner and do some volunteering in the form of school governor, teacher at “Le Petite École de Leeds” on Saturdays, and official on a couple of football governing bodies.

Responsibilities

  • FMH School of Medicine Research Ethics Committee Member
  • LICAMM Buildings and Facilities User Group Representative

Research interests

Molecular mechanisms in thrombosis and thromboembolism

My research focuses on understanding the mechanisms involved in thrombosis and thromboembolism. In particular, I am focusing on understanding the role of fibrinogen and coagulation factor (F)XIII in fibrin clot structure and stability.

Cardiovascular disease (CVD), is the most common cause of morbidity and mortality in the Western World. In Europe alone, it is responsible for 4.3 million deaths per year and as much as 35% of all deaths in the UK are attributed to CVD. The development of a thrombus in CVD patients is the ultimate cause of death. The role of the fibrin clot itself is poorly defined in relation to thrombus formation, stability and thrombolysis.

My research aims to elucidate the roles of 1) fibrinogen alpha- and gamma-chains, 2) FXIII cross-linking, 3) fibrinolysis inhibitors, on clot formation and stability, and their roles in thrombosis and thromboembolism.

Most of the methods used in these projects range from molecular biology (generation and expression of recombinant proteins) to biochemistry (purification and analysis of proteins), biophysics (atomic force microscopy, confocal and electron microscopy, magnetic tweezers), and in-vivo studies.

Recent Projects

  • Boston Scientific International Industry Funding, £77,098; 2021-2022. The basic science of clot formation and treatment with eKOS: Role of clot properties in eKOS ultrasound-mediated thrombolysis. Awarded to RAS Ariëns, C Duval.
  • British Heart Foundation Programme Grant, £1,323,069; 2019-2024, RG/18/11/34036. Role of fibrin biofilm and clot network architecture in thrombus stability. Awarded to RAS Ariëns, NY Yuldasheva, SD Connell, VC Ridger, JP Greenwood, RA Ajjan, H Philippou.
  • Medical Research Council Genome Editing Mice for Medicine Award, circa £55,000; 2018-2020. Generation of a FGA-4X murine model: Role of fibrin alpha-chain cross-linking in fibrin clot stability and thrombosis. Awarded to C Duval, RAS Ariëns.
  • Medical Research Council Genome Editing Mice for Medicine Award, circa £55,000; 2016-2018. Generation of FXIIIA-34Val murine model: Role in atherothrombosis and venous thromboembolism. Awarded to C Duval, RAS Ariëns.
  • British Heart Foundation PhD Studentship, £107,059; 2015-18, FS/15/37/31513. Role of extended knob-hole interaction sites in fibrin polymerisation and clot stability. Awarded to MM Domingues, C Duval, RAS Ariëns.
  • British Heart Foundation Programme Grant, £1,145,224; 2013-2018, RG/13/3/30104. Mechanisms of fibrin structure in thrombosis. Awarded to RAS Ariëns, H Philippou, SD Connell, R Ajjan, VC Ridger.
  • Medical Research Council Project Grant, £400,000; 2010-2013, G0901546. Role of coagulation factor XIII in fibrin clot structure and thrombosis. Awarded to RAS Ariëns, H Philippou, VC Ridger.

Qualifications

  • PhD in Gastric Cellular and Molecular Physiology (University of Liverpool)
  • MRes in Cellular and Molecular Physiology (University of Liverpool)
  • Diplôme d’Études Approfondies (MRes) in Cellular Biology and Physiology (University of Nice, France)
  • Maîtrise (MSc) in Cellular Biology and Physiology, (University of Rennes, France)
  • Licence (BSc) in Cellular Biology and Physiology (University of Rennes, France)

Professional memberships

  • Associate Fellow of the Higher Education Academy
  • Member of the ISTH (International Society on Thrombosis and Haemostasis)
  • Member of the IFRS (International Fibrinogen Research Society)
  • Member of the BSHT (British Society for Haemostasis and Thrombosis)
  • BSHT Committee Member
  • Frontiers in Cardiovascular Medicine, Thrombosis Review Editor

Student education

PhD supervisor

  • Ghadir Alkarithi (2019-23): Role of fibrin biofilm in haemostasis and thrombosis.
  • Adomas Baranauskas (2016-19): Understanding the role of coagulation Factor XIII in the development of venous and arterial thrombosis. Thesis successfully defended January 2020. Next position: Business Data Analyst at Barrett Steel.
  • Aliaa Sabban (2015-19): Characterisation of the erythrocyte binding site on fibrinogen; Implications for clot structure and thrombosis. Thesis successfully defended May 2019. Next position: Assistant Professor in the Faculty of Medicine, King Abdulaziz University, Jedah, Saudi Arabia (Prof Qari).
  • Nathan Asquith (2015-18): Role of extended knob-hole interaction sites in fibrin polymerisation and clot stability. Thesis successfully defended December 2018. Next Position: Postdoctoral Researcher at Harvard Medical School, Boston, MA, USA (Dr Italiano).

Medicine Intercalated BSc supervisor

  • Milad Mossanen-Parsi (Medicine Intercalated BSc, 2020/21): Thrombus properties in myocardial infarction patients.
  • Matthew Gold (Medicine Intercalated BSc, 2016/17): Role of Fibrinogen alpha-chain in fibrin clot formation, structure and stability.
  • Eloisa MacLachlan (Medicine Intercalated BSc, 2015/16): The development of novel murine tools to study the role of FXIII V34L in thrombosis.
  • Thomas Riley (Medicine Intercalated BSc, 2014/15): Effects of fibrinogen gamma’ peptides on clot structure and stability.
  • Christina Hitchen (Medicine Intercalated BSc, 2013/14): Effects of Fibrinogen gamma' on structure and stability of blood clots.
  • Waleed Chaudhry (Medicine Intercalated BSc, 2012/13): Kinetics of Factor XIII activation and fibrin clot structure.

Lecturer and Tutor in other Undergraduate Medical Programmes

  • MEDI1216 Introduction to Medical Sciences.
  • ARCS1102 The Biological Basis of Healthcare Science.
  • MEDI121801 Research Evaluation and Special Studies – Special Studies Research Project.
  • MEDI1213  Research Evaluation and Special Studies – Human Body Measurements.

Research groups and institutes

  • Leeds Institute of Cardiovascular and Metabolic Medicine
  • Discovery and Translational Science
<h4>Postgraduate research opportunities</h4> <p>We welcome enquiries from motivated and qualified applicants from all around the world who are interested in PhD study. Our <a href="https://phd.leeds.ac.uk">research opportunities</a> allow you to search for projects and scholarships.</p>