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Professor Khalid Naseem

  • Position: Chair in Cardiovascular Sciences
  • Areas of expertise: Platelet Biology; Thrombosis; Cell Signalling
  • Email: K.Naseem@leeds.ac.uk
  • Location: 7.13 LIGHT

Profile

I undertook PhD and post-doctoral studies at the Royal Free and University College London School of Medicine, before being appointed as a Lecturer at the University of Bradford. I was then appointed as the Foundation Chair in Biomedical Sciences. at the Hull-York Medical School. In 2017 I took up the post of Professor of Cardiovascular Biology at the University of Leeds.

Responsibilities

  • Director of LICAMM
  • Director – British Heart Foundation Accelerator Award

Research interests

Research in my laboratory uses pharmacological, transgenic and gene-targeted strategies to determine the causality of maladaptive platelet functions in human disease in order to provide new sites of therapeutic interventions that target platelet driven disease processes. My laboratory focusses on two interrelated areas:

Platelet function and thrombotic risk in cardiometabolic diseases

Our work is focused on patient benefit and in particular understanding the basis of abnormal pletelt function in the context of cardiovascular disease including acute coronary syndromes, insulin resistant states and peripheral vascular disease.  Our work in focused on “deep phenotyping’ of blood platelets using molecular, biochemical and functional approaches

The role of atherogenic lipid stress in promoting platelet hyperactivity and thrombosis.

This programme for work is focussed on understanding the role of scavenger receptor CD36 in promoting platelet driven arterial thrombosis in a hyperlipidaemic environment. We are currently exploring the signaling pathways linked to this receptor, its role in promoting platelet hyperactivity in patients at risk of thrombosis and developing therapeutic agents to mitigate this risk.

Research in my laboratory is funded by the BBSRC, British Heart Foundation, Heart Research UK and the MRC.

Current grants

  • British Heart Foundation Accelerator Award. (2024-2029). Diabetic Heart Failure- cells, crosstalk and consequences. KM Naseem, M Kearney (PIs)
  • British Heart Foundation Intermediate Basic Science fellowship. (2023-2028). Factor XIII-A V34L variant and inflammation in thromboembolism  C Duval (PI) RA Ariens, KM Naseem.
  • British Heart Foundation PhD Studentship. (2023-2026). Targeting the myosin light chain phosphatase with peptide disruptors: a novel antiplatelet therapeutic approach. F Rivero (PI) KM Naseem
  • British Heart Foundation Project Grant. (2023-2026) Pinpointing the platelet GPVI binding site on the fibrinogen alpha-chain: Implications for platelet and fibrin driven blood clotting. RA Ariens (PI), R Xu, KM Naseem                 
  • British Heart Foundation Programme Grant. (2022 – 2027). Dysregulation of platelet phosphodiesterase 3A isoforms promote platelet hyperactivity in atherothrombotic disease. KM Naseem (PI), M Kearney, S Wheatcroft, R Ajjan, G Baillie       
  • British Heart Foundation Programme Grant. (2022 – 2026). A novel signalling node pivotal to type 2 diabetes related vascular damage.  M Kearney (PI), R Cubbon, S Wheatcroft, D Beech, KM Naseem, N Yuldasheva, P.Sukumar
  • British Heart Foundation Project Grant (2022-2025). Characterising the role of BACE-1 in platelet function, haemostasis and thrombosis.  KM Naseem (PI), P Meakin, R Ariens    
  • Heart Research UK PhD studentship (2022-2025) Identification and characterisation of prothrombotic platelet subpopulations in acute coronary syndromes – a pilot study.  KM Naseem (PI), M Kearney
  • BBSRC Project Grant (2021-2024). Fibrinogen-targeted conformational proteins for identification of the mechanistic pathways controlling fibrin network stability.  R Ajjan (PI), D Tomlinson, Tiede, R Ariens, K Naseem, Simmons, Edwards, V Ridger and R Storey.
  • BBSRC Project Grant (2021-2025) Conformational proteins to study molecular mechanisms underpinning GPVI-fibrin(ogen) interaction in blood clot propagation.  R Ariens (PI), A Calabrese, K Naseem, C Tiede, D Tomlinson, C Trinh, S Watson, R Xu       

External positions

  • British Heart Foundation 2019- 2023   Project grant committee.
  • Platelets (Journal) 2017-2022  Principal Editor.
  • The Platelet Society  2017-2019  Inaugural President.
  • Heart Research UK  2014-2019  Chair, Medical Review Panel.

Qualifications

  • BSc (Hons)
  • PhD

Professional memberships

  • Biochemical Society
  • British Cardiovascular Society
  • British Society for Haemostasis and Thrombosis
  • International Society for Thrombosis and Haemostasis
  • Platelet Society

Research groups and institutes

  • Leeds Institute of Cardiovascular and Metabolic Medicine
  • Discovery and Translational Science
  • British Heart Foundation - Cardiovascular research
  • Multidisciplinary Cardiovascular Research Centre
<h4>Postgraduate research opportunities</h4> <p>We welcome enquiries from motivated and qualified applicants from all around the world who are interested in PhD study. Our <a href="https://phd.leeds.ac.uk">research opportunities</a> allow you to search for projects and scholarships.</p>
Projects
    <li><a href="//phd.leeds.ac.uk/project/1352-licamm-molecular-characterization-and-functional-roles-of-volume-regulated-ion-channels-in-platelets">LICAMM Molecular characterization and functional roles of volume-regulated ion channels in platelets</a></li> <li><a href="//phd.leeds.ac.uk/project/194-licamm-the-role-of-platelet-dysfunction-in-promoting-diabetic-thrombo-inflammation.">LICAMM The role of platelet dysfunction in promoting diabetic thrombo-inflammation.</a></li>