Dr Md Yuzaiful Md Yusof

Dr Md Yuzaiful Md Yusof

Profile

I am an NIHR Academic Clinical Lecturer within the Leeds Institute of Rheumatic and Musculoskeletal Medicine and ST6 Specialist Registrar in Rheumatology. I graduated from Manchester Medical School, the University of Manchester in 2008. Having completed my Foundation, Core Medical Training and obtained my medical membership (MRCP) in 2012 in the North West region, I relocated to Leeds to pursue a career in academic medicine. I was awarded an NIHR Academic Clinical Fellow at the Specialist Registrar level. After spending two years in this post, I was successful in securing the prestigious NIHR Doctoral Research Fellowship in 2014 to undertake a PhD programme at the University of Leeds. The title of my thesis was "Personalised Therapy Based on Immunopathogenesis to Improve Outcomes of At-Risk and Established Systemic Lupus Erythematosus." During my PhD training, I was the Runner-up in the University of Leeds Post-Graduate Researcher of the Year 2017 competition. I was awarded a PhD from the University of Leeds in December 2018. Currently, I am working on to secure an Advanced Fellowship or Clinician Scientist Fellowship to enable me to continue my research works.

Outside LIRMM, I am currently appointed as the Emerging European Rheumatologist Network (EMEUNET) Working Group Member (Newsletter Sub-Group) and a member of the EULAR Task Force for "Points to Consider on Assessment of Competences in Rheumatology."  I am also appointed as the British Isles Lupus Assessment Group (BILAG) Renal Sub-Committee in order to revise and update the current scoring scheme.

Research interests

I am a translational researcher and the theme of my research is personalised therapy. My research is focused around two conditions that share common immunopathogenesis; systemic lupus erythematosus and primary Sjogren's syndrome. Since both diseases are heterogenous in terms of clinical presentation and response to therapy, there are no one-size-fits-all therapies for these conditions. Hence, I am interested in dissecting mechanism of resistance to therapy, phenotyping patients who will respond best, improving outcome measures and translating novel agents from bench to bedside by running a clinical trial.

Grants received:

1. Lupus UK Grant (Co-applicant) - £25 000  (November 2017)

"Dissecting the role of interferons in the onset of systemic lupus erythematosus"

2. NIHR Doctoral Research Fellowship Award (DRF) - £511 468  (December 2014)

"Selecting the Right Biologic for the Right Patient in Systemic Lupus Erythematosus (SLE): Personalised Therapy based on Immunopathogenesis."

3. Pfizer Inflammation Investigator-initiated Research (IIR) Grant (Co-applicant)  (July 2014)

Awarded the supply of Etanercept free of charge for "Targeted therapy using intradermal injection of Etanercept for remission induction in Discoid Lupus Erythematosus (TARGET-DLE)" Phase 2 trial

Qualifications

  • Doctor of Philosophy (PhD), University of Leeds
  • MRCP (UK), Royal College of Physicians
  • MBChB, University of Manchester
  • Post-Graduate Diploma in Health Research, University of Leeds
  • Post-Graduate Certificate in Health Research, University of Leeds

Professional memberships

  • General Medical Council
  • Royal College of Physicians Edinburgh
  • Medical Defence Union

Student education

I am actively involved in the undergraduate teaching by delivering a lecture once a month on "Connective Tissue Disease" and organise Hands Examination session (2-monthly). I am also one of the Final Year OSCE examiners at both the University of Leeds and University of Manchester. I recently supervised two undergraduate students as a part of the LEADERS Summer School Projects and both of them managed to get poster presentations at the national conference and publication in a 3-star journals. I have also delivered lectures to the post-graduate Core Medical Trainee and Specialist Registrar.

Research groups and institutes

  • Leeds Institute of Rheumatic and Musculoskeletal Medicine