Dr Paul Meakin

Dr Paul Meakin


  • I completed my degree at the University of Nottingham, in Biochemistry and Biological Chemistry (MSci) in 2004.
  • In 2005 I moved to the University of Dundee to undertake a PhD with Professor Mike Ashford, on the role of the ß-secretase enzyme, in whole animal energy homeostasis.
  • Between 2009 and 2018 I worked in Professor Ashford’s lab researching the hormonal balance of energy homeostasis, type 2 diabetes and obesity.
  • In 2018, I was awarded a BHF Intermediate Basic Science Research Fellowship and joined the University of Leeds as a senior research fellow.
  • co-lead of the Physiology Society’s Metabolic Physiology Theme (2019-2022).
  • British Microcircualtion Society Ordinary Committee member (2019-2022).

Research interests

  • Cardiovascular disease is the biggest cause of mortality and morbidity for individuals with Type 2 diabetes. The risk of developing Alzheimer’s disease is also significantly increased.
  • The aim of my lab is to understand why and how these diseases are linked, in order to find new ways to prevent their long-term harmful consequences.
  • Of particular interest is the ß-secretase enzyme, BACE1. We are aiming to determine the physiological and pathological functions of BACE1 and establish it as an attractive therapeutic target for Type 2 diabetes and its co-morbidities. 


  • MSci Biochemistry and Biological chemistry
  • PhD

Professional memberships

  • Diabetes UK
  • British Society for Cardiovascular Research
  • British Microcirculation Society
  • The Physiology Society
  • The Endocrinology Society
  • The Biochemistry Society

Research groups and institutes

  • Leeds Institute of Cardiovascular and Metabolic Medicine
  • Discovery and Translational Science
  • Cardiometabolic
  • British Heart Foundation - Cardiovascular research
  • Multidisciplinary Cardiovascular Research Centre
<h4>Postgraduate research opportunities</h4> <p>We welcome enquiries from motivated and qualified applicants from all around the world who are interested in PhD study. Our <a href="https://phd.leeds.ac.uk">research opportunities</a> allow you to search for projects and scholarships.</p>
    <li><a href="//phd.leeds.ac.uk/project/1483-cancer:-repurposing-drugs-as-new-treatments-for-breast-cancer">Cancer: Repurposing drugs as new treatments for breast cancer</a></li> <li><a href="//phd.leeds.ac.uk/project/1351-ion-channel-regulation-in-cardiovascular-disease">Ion channel regulation in cardiovascular disease</a></li> <li><a href="//phd.leeds.ac.uk/project/519-repurposing-bace1-inhibitors-for-cardiovascular-disease">Repurposing BACE1 inhibitors for cardiovascular disease</a></li>