Dr Paul Meakin

Dr Paul Meakin

Profile

  • I completed my degree at the University of Nottingham, in Biochemistry and Biological Chemistry (MSci) in 2004.
  • In 2005 I moved to the University of Dundee to undertake a PhD with Professor Mike Ashford, on the role of the ß-secretase enzyme, in whole animal energy homeostasis.
  • Between 2009 and 2018 I worked in Professor Ashford’s lab researching the hormonal balance of energy homeostasis, type 2 diabetes and obesity.
  • In 2018, I was awarded a BHF Intermediate Basic Science Research Fellowship and joined the University of Leeds as a senior research fellow.

Research interests

  • Cardiovascular disease is the biggest cause of mortality and morbidity for individuals with Type 2 diabetes. The risk of developing Alzheimer’s disease is also significantly increased.
  • The aim of my lab is to understand why and how these diseases are linked, in order to find new ways to prevent their long-term harmful consequences.
  • Of particular interest is the ß-secretase enzyme, BACE1. We are aiming to determine the physiological and pathological functions of BACE1 and establish it as an attractive therapeutic target for Type 2 diabetes and its co-morbidities. 

Qualifications

  • MSci Biochemistry and Biological chemistry
  • PhD

Professional memberships

  • Diabetes UK
  • British Society for Cardiovascular Research
  • British Microcirculation Society
  • The Physiology Society
  • The Endocrinology Society
  • The Biochemistry Society

Research groups and institutes

  • Leeds Institute of Cardiovascular and Metabolic Medicine
  • Discovery and Translational Science
  • Cardiovascular
  • British Heart Foundation - Cardiovascular research
<h4>Postgraduate research opportunities</h4> <p>We welcome enquiries from motivated and qualified applicants from all around the world who are interested in PhD study. Our <a href="https://phd.leeds.ac.uk">research opportunities</a> allow you to search for projects and scholarships.</p>
Projects
    <li><a href="//phd.leeds.ac.uk/project/444-identifying-bace1-inhibitors-as-novel-therapies-for-cardiovascular-disease">Identifying BACE1 inhibitors as novel therapies for cardiovascular disease</a></li> <li><a href="//phd.leeds.ac.uk/project/325-identifying-bace1-inhibitors-as-novel-therapies-for-cardiovascular-disease">Identifying BACE1 inhibitors as novel therapies for cardiovascular disease</a></li> <li><a href="//phd.leeds.ac.uk/project/333-investigation-into-the-regulation-of-novel-substrates-of-bace1-in-cardiometabolic-disease">Investigation into the regulation of novel substrates of BACE1 in cardiometabolic disease</a></li> <li><a href="//phd.leeds.ac.uk/project/519-repurposing-bace1-inhibitors-for-cardiovascular-disease">Repurposing BACE1 inhibitors for cardiovascular disease</a></li> <li><a href="//phd.leeds.ac.uk/project/329-targeting-bace1-to-improve-angiogenesis-in-type-2-diabetes">Targeting BACE1 to improve angiogenesis in type 2 diabetes</a></li> <li><a href="//phd.leeds.ac.uk/project/330-understanding-the-role-of-metabolic-disease-in-vascular-dementia">Understanding the role of metabolic disease in vascular dementia</a></li>