- Bloodwise-funded Project
My research interests aim to investigate the molecular mechanisms regulating apoptosis in response to mitogenic signals such as pro-inflammatory cytokines and oncogenic stimuli and to understand the molecular mechanisms of lymphocytes differentiation in human disease. In particular, Research in the Papa's lab is broadly focused on the understanding of the molecular mechanisms regulating programmed cell death and survival.
The fields of programmed cell death have become the foundation of biomedical research, central to both fundamental biology and the understanding of a broad range of human diseases ranging from cancer to inflammatory and neurodegenerative diseases. At the molecular level, the group focus on the post-translational modifications, the study of the covalent modification of proteins during or after protein biosynthesis. Most of our efforts to date have concentrated on phosphorylation, which is one of the most fundamental types of post-translational modification in eukaryotic cells. We are interested in the regulation and activity of a group of serine/threonine (Ser/Thr) protein kinases known as c-Jun N-terminal kinases (JNKs), master regulators of a large variety of cellular functions including apoptosis, differentiation, cell survival and proliferation.
- 'Laurea' Doctorate in Medical Biotechnology (5 years course)
- PhD in Molecular Medicine
- Post-Doctoral Training in Immunology & Cancer Biology
Research groups and institutes
- Leeds Institute of Medical Research at St James's