Dr Tim W.R. Lee

Profile

Dr Tim Lee is Head of Studies for the Postgraduate Programmes in Child Health, one of the largest Postgraduate Programmes within the School of Medicine. This exciting Programme seeks to inspire and develop the next generation of leaders in Child Health. He is also Lead Clinician and Consultant at the Leeds Regional Paediatric Cystic Fibrosis Centre. He has been involved in the clinical care of children and young people with cystic fibrosis since 1995. He has a PhD focussed on improving the effectiveness of gene therapy, and is Principal Investigator on a number of current clinical trials. Leeds is part of the European Cystic Fibrosis Society Clinical Trial Network, which comprises 43 large and experienced CF Centres across 15 European countries, caring for a total of 17,500 people with CF. The aim of the ECFS-CTN is to increase the quality and quantity of CF clinical research by having a co-ordinated approach to realizing efficient and high-quality clinical trials addressing the most important priorities for people with CF. He also represents ECFS-CTN on the coordinating group of Enpr-EMA, the network of paediatric research networks at the European Medicines Agency. He also is NIHR Children’s Theme Specialty Lead for Yorkshire and Humber, working to support children and young people throughout Yorkshire and Humber having appropriate opportunities to access clinical trials, wherever they live. Tim works closely with children’s research nurses and children’s research clinical leads across all hospital Trusts in Yorkshire and Humber.

Recent Research Publications

G. Bowmer, G. Latchford, A. Duff, L. Dye, C. Lawton, M. Denton, T. Lee. Adherence to infection prevention and control guidelines: a vignette-based study of decision-making and risk-taking in young adults with CF. Journal of Cystic Fibrosis 2017;16: 146-150

W. Kuo, M.P.C. Kemner-van de Corput, A. Perez-Rovira, M. de Bruijne, I. Fajac, H. A.W.M. Tiddens, M. van Straten, ECFS-CTN/SCIFI CF study group. Multicentre chest computed tomography standardisation in children and adolescents with cystic fibrosis: the way forward. European Respiratory Journal 2016; 47: 1706-1717

D. Peckham, C. Etherington, H. White, T. Lee, et al. The development and deployment of integrated electronic care records in a regional adult and paediatric cystic fibrosis unit. Journal of Cystic Fibrosis 2014; 13: 681-686

Fajac I, Bulteel V, Castellani C, Lee T, et al. The European Cystic Fibrosis Society–Clinical Trials Network: an international network to optimize clinical research for a rare disease. Clin. Invest. 2013; 3(10): 921–926.

Reynolds L, Latchford G, Duff A, Denton M, Lee T, and Peckham DG. Decision-making about risk of infection by young adults with Cystic Fibrosis. Pulmonary Medicine 2013 Article ID 658638.

De Boeck K, Bulteel V, Tiddens H, Wagner T, Fajac I, Conway S, Dufour F, Smyth A, Lee T, Sermet I, Kassai-Koupai B, Elborn S. Guideline on the design and conduct of cystic fibrosis clinical trials: The European Cystic Fibrosis Society – Clinical Trial Network (ECFS-CTN). Journal of Cystic Fibrosis 2011; 10(S2): S67-S74

Whitaker P, Brownlee KG, Lee TWR, Etherington C, Conway SP, Peckham D. Sequential bronchoscopy in the management of lobar atelectasis in patients with cystic fibrosis. Journal of Bronchology and Interventional Pulmonology 2011; 18: 57-60

Barton RC, Borman AM, Johnson EM, Houbraken J, Hobson RP, Denton M, Conway SP, Brownlee KG, Peckham D, Lee TWR. Isolation of the fungus Geosmithia argillacea in the sputum of people with cystic fibrosis.Journal of Clinical Microbiology 2010; 48; 2615-7

Guy EL, Peckham D, Conway SP, Brownlee KG, Lee TWR. Cystic Fibrosis co-existing with Trisomy 21.

Journal of Cystic Fibrosis 2010; 9: 330-331

Jagannath VA, Asokan GV, Fedorowicz Z, Singaram JS, Lee TWR. Neuraminidase inhibitors for the treatment of influenza infection in people with cystic fibrosis (Review) The Cochrane Library 2010; Issue 5.

Guy EL, Bosomworth M, Denton M, Conway SP, Brownlee KG, Lee TWR. Serum tobramycin levels following delivery of tobramycin (TOBI®) by E-flow® advanced nebuliser in children with cystic fibrosis. Journal of Cystic Fibrosis 2010; 9: 292-295

Ball R, Brownlee KG, Duff AJA, Denton M, Conway SP, Lee TWR. Can Burkholderia cepacia complex be eradicated with nebulised Amiloride and TOBI®? Journal of Cystic Fibrosis Journal of Cystic Fibrosis 2010; 9: 73-74

Jagannath VA, Asokan GV, Fedorowicz Z, Singaram JS, Lee TWR. Neuraminidase inhibitors for the treatment of influenza infection in people with cystic fibrosis (protocol). The Cochrane Library 2009; Issue 4.

Conway SP, Lee TWR. Prevention of chronic Pseudomonas aeruginosa infection in people with cystic fibrosis. Expert Review of Respiratory Medicine 2009; 3: 349-361

Lee TWR. Eradication of early Pseudomonas infection in cystic fibrosis. Chronic Respiratory Disease 2009; 6: 99-107

Ho SA, Lee TWR, Conway SP, Brownlee KG, Denton M. Regimens for eradicating early Pseudomonas aeruginosa infection in children do not promote antibiotic resistance in this organism. Journal of Cystic Fibrosis 2009; 8: 46-48

Lee TWR, Blair GE. Gene Therapy for Cystic Fibrosis: Not as easy as it looks. The Biochemist, June 2008: 2-5

Lee TWR, Conway SP, Peckham D, Brownlee KG. Respiratory exacerbations in childhood associated with compound heterozygosity phe508del/Arg117His-7T of the cystic fibrosis transmembrane regulator gene. Acta Paediatrica 2008; 97: 670-672

Lee TWR, Southern KW. Topical cystic fibrosis transmembrane regulator gene replacement for cystic fibrosis related lung disease (Review). The Cochrane Library 2007; Issue 2.

Lee TWR, Matthews DA, Blair GE. Novel molecular approaches to cystic fibrosis gene therapy. Biochemical Journal 2005; 387: 1-15.

Doring G, Hoiby N, Consensus Study Group. Early intervention and prevention of lung disease in cystic fibrosis: a European consensus. Journal of Cystic Fibrosis 2004; 3: 67-91.

Lee TWR, Brownlee KG, Denton M, Littlewood JM, Conway SP. Reduction in prevalence of chronic Pseudomonas aeruginosa infection at a regional paediatric cystic fibrosis centre. Pediatric Pulmonology 2004; 37: 104-110.

Lee TWR, Brownlee KG, Conway SP, Denton M, Littlewood JM. Evaluation of a new definition for chronic Pseudomonas aeruginosa infection in cystic fibrosis patients. Journal of Cystic Fibrosis 2003; 2: 29-34. 

Responsibilities

• Head of Studies, Postgraduate Programmes in Child Health
• NIHR Children's Theme Specialty Lead, Yorkshire and Humber

Qualifications

• BSc Hons Pharmacology Leeds 1991
• MB ChB with Honours Leeds 1994
• MMedSc Child Health with Distinction Leeds 2001
• PhD Leeds 2004
• MRCPCH 1997

Research groups and institutes

• Leeds Institute of Medical Education