Professor Sarah R Brown
I am Professor of Cancer Clinical Trials Methodology and the Director of Early Phase Trials in Cancer Division.
I am deputy director of the Leeds Cancer Research UK Clinical Trials Unit and co-director of the Myeloma UK Concept and Access Research Programme.
I started my career as a medical statistician at Leeds CTRU in 2003, gaining my PhD in phase II trial design in 2012 and subsequently establishing and developing the early phase trials division.
I specialise in phase I and II trials methodology in oncology, with particular focus in myeloma and radiotherapy. I have a broad range of experience with various funding bodies including charity, government and industry partnerships.
I sit on a number of external committees including as a member of the CRUK Clinical Research Committee, Blood Cancer UK Clinical Trials Review Committee, past co-chair of NCRI CTRad workstream 2 (early phase), and I am a faculty member for the international Methods in Clinical Cancer Research workshop.
- Director of Early Phase Trials in Cancer Division
I am interested in the design and conduct of phase I and II cancer clinical trials. In particular I am interested in the application of novel and efficient early phase trial designs, evaluating multiple experimental therapies in a single trial protocol.
I am methodological lead for the CONCORDE trial, a phase I platform trial evaluating multiple radiotherapy-DDRi combinations in lung cancer.
This trial applies the TiTE-CRM design to multiple experimental arms, with the aim of identifying recommended phase II doses for each combination.
- PhD Statistics - University of Leeds
- MSc Medical Statistics - Lancaster University
- BSc Mathematics - University of Hull
- CRUK Clinical Research Committee
- NCRI CTRad
- NCRI Multiple Myeloma Subgroup (member)
- Methods in Clinical Cancer Research workshop (faculty)
- Blood Cancer UK Clinical Trials Review Committee
I co-developed the MSc in Biopharmaceutical Development as the Clinical Module Lead.
I have supervised one PhD to completion and am currently supervisor to four PhD students, with research projects including the design of phase I trials and personalisation of re-irradiation therapy directed by MRI and hypoxia markers.
Research groups and institutes
- Leeds Institute of Clinical Trials Research