Dr Sarah R Brown
I am Associate Professor of Statistics in Early Phase Clinical Trials and the Director of Early Phase Trials in Cancer Division. I started my career as a medical statistician at Leeds CTRU in 2003, gaining my PhD in phase II trial design in 2012 and subsequently establishing and developing the early phase trials division. I specialise in phase I and II trials methodology in oncology, with particular focus in myeloma and radiotherapy. I have a broad range of experience with various funding bodies including charity, government and industry partnerships. I sit on a number of external committees including co-chairing NCRI CTRad workstream 2, member of the CRUK Experimental Medicine Expert Review Panel, and am on the faculty for the international Methods in Clinical Cancer Research workshop.
- Director of Early Phase Trials in Cancer Division
I am interested in the design and conduct of phase I and II cancer clinical trials. In particular i am interested in the application of novel and efficient early phase trial designs, evaluating multiple experimental therapies in a single trial protocol. I am methodological lead for the CONCORDE trial, a phase I platform trial evaluating multiple radiotherapy-DDRi combinations in lung cancer. This trial applies the TiTE-CRM design to multiple experimental arms, with the aim of identifying recommended phase II doses for each combination.
- PhD Statistics - University of Leeds
- MSc Medical Statistics - Lancaster University
- BSc Mathematics - University of Hull
- CRUK Experimental Medicine Expert Review Panel
- NCRI CTRad Workstream 2 (co-Chair)
- NCRI Multiple Myeloma Subgroup (member)
- Methods in Clinical Cancer Research workshop (faculty)
I co-developed the MSc in Biopharmaceutical Development as the Clinical Module Lead.
I am currently PhD supervisor to 3 PhD students, with research projects investigating the design of phase I and II trials, and presonalisation of re-irradiation therapy directed by MRI and hypoxia markers
Research groups and institutes
- Leeds Institute of Clinical Trials Research