Dr Sarah R Brown

Dr Sarah R Brown

Profile

I am Associate Professor of Statistics in Early Phase Clinical Trials and the Director of Early Phase Trials in Cancer Division. I started my career as a medical statistician at Leeds CTRU in 2003, gaining my PhD in phase II trial design in 2012 and subsequently establishing and developing the early phase trials division. I specialise in phase I and II trials methodology in oncology, with particular focus in myeloma and radiotherapy. I have a broad range of experience with various funding bodies including charity, government and industry partnerships. I sit on a number of external committees including co-chairing NCRI CTRad workstream 2, member of the CRUK Experimental Medicine Expert Review Panel, and am on the faculty for the international Methods in Clinical Cancer Research workshop. 

 

Responsibilities

  • Director of Early Phase Trials in Cancer Division

Research interests

I am interested in the design and conduct of phase I and II cancer clinical trials. In particular i am interested in the application of novel and efficient early phase trial designs, evaluating multiple experimental therapies in a single trial protocol. I am methodological lead for the CONCORDE trial, a phase I platform trial evaluating multiple radiotherapy-DDRi combinations in lung cancer. This trial applies the TiTE-CRM design to multiple experimental arms, with the aim of identifying recommended phase II doses for each combination. 

Qualifications

  • PhD Statistics - University of Leeds
  • MSc Medical Statistics - Lancaster University
  • BSc Mathematics - University of Hull

Professional memberships

  • CRUK Experimental Medicine Expert Review Panel
  • NCRI CTRad Workstream 2 (co-Chair)
  • NCRI Multiple Myeloma Subgroup (member)
  • Methods in Clinical Cancer Research workshop (faculty)

Student education

I co-developed the MSc in Biopharmaceutical Development as the Clinical Module Lead.

I am currently PhD supervisor to 3 PhD students, with research projects investigating the design of phase I and II trials, and presonalisation of re-irradiation therapy directed by MRI and hypoxia markers

 

 

Research groups and institutes

  • Leeds Institute of Clinical Trials Research
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