Dr Fiona Bartoli
- Position: Research Fellow
- Areas of expertise: Cardiovascular diseases, Heart failure, Cardiac and vascular physiology, Ion channels, Calcium signalling and imaging, Molecular biology.
- Email: F.Bartoli@leeds.ac.uk
- Location: LICAMM Level 7 LIGHT Laboratories
- Website: ORCID
I graduated from the University of Poitiers in France with a BSc and MSc (Hons) in Physiology and Neurosciences. I did a PhD in the Inserm UMR-S 1180 laboratory at the University of Paris-Saclay in France, investigating the role of Orai1 channels in cardiac pathophysiology. My PhD was awarded in 2018. Then, I moved to the UK to work as a British Heart Foundation (BHF) funded postdoctoral research fellow for Prof. David Beech at the University of Leeds, researching the regulation of whole body physical activity by endothelial Piezo1 channels. In 2021, I was awarded a Mautner BHF Career Development fellowship as a first step towards research independence.
I am primarily interested in calcium channels, mostly voltage-independent channels such as TRPC, Orai1 and Piezo1 channels. My research focuses on understanding the role of these calcium channels in the cardiovascular system, heart and blood vessels. During my PhD, we have identified Orai1 channels as a key actor in HF and cardiac fibrosis development with an improvement of the cardiac function when Orai1 channels are blocked with a selective small molecule inhibitor developed in the University of Leeds. My postdoctoral work helped understand the role of endothelial Piezo1 channels in the regulation of whole body physical activity.
- PhD Cardiac pathophysiology
- MSc Physiology and Neurosciences
- BSc Physiology and Neurosciences
Research groups and institutes
- Leeds Institute of Cardiovascular and Metabolic Medicine
- Multidisciplinary Cardiovascular Research Centre