Professor Ulf Klein

Professor Ulf Klein


I graduated from the University of Cologne in 1993 with a diploma in biology, which included a year abroad at King’s College London where I studied biochemistry (non-award).

I completed my PhD, in which I specialized in immunology, at the University of Cologne in 1998.

I moved to Columbia University, New York City, for my postdoctoral research, supported by EMBO and HFSP fellowships. I stayed at Columbia as an Associate Research Scientist from 2003.

In 2009, I accepted an offer from Columbia University to establish my independent research group as Assistant Professor of Pathology & Cell Biology and Microbiology & Immunology. I was promoted to Associate Professor with tenure in 2016.

In January 2017, I was appointed as Professor in Immunology and Haemato-oncology at the University of Leeds, where I lead the Molecular Haematology group in the Leeds Institute of Medical Research (LIMR) at St. James's.


  • Head of the Molecular Haematology Group

Research interests

The goal of my research group is to understand the oncogenic mechanisms that cause malignant transformation of mature B cells and plasma cells.

Cancers of the B-cell lineage, lymphomas and multiple myeloma, can be very aggressive, and often the cancer rapidly reoccurs after standard therapy. Thus, there is a clinical need for more effective therapies against these malignancies, which requires a better understanding of the biology of these cancers.

My laboratory focusses on the elucidation of the molecular mechanisms that govern the differentiation of B cells. We aim to understand how the disruption of these mechanisms by genetic mutations leads to the development of B-cell and plasma cell malignancies.

The research is expected to identify Achilles’ heels in the tumour cells that are vulnerable for intervention with anti-cancer drugs. This is a prerequisite for the realization of precision medicine in the treatment of haematological malignancies.


  • PhD in Genetics
  • Diploma in Biology

Professional memberships

  • American Society of Hematology
  • American Association of Immunologists
  • British Society for Immunology
  • German Society for Immunology (DGfI)

Student education

I teach students in the MSc Molecular Medicine course and I supervise PhD students.

Research groups and institutes

  • Leeds Institute of Medical Research at St James's
  • Cancer
  • Immunity and inflammation
<h4>Postgraduate research opportunities</h4> <p>We welcome enquiries from motivated and qualified applicants from all around the world who are interested in PhD study. Our <a href="">research opportunities</a> allow you to search for projects and scholarships.</p>
    <li><a href="//">LIMR Haematology: Oncogenic mechanisms causing malignant transformation of B cells and plasma cells</a></li>