Dr Emily Caseley
I obtained my PhD in molecular biology in 2016 from the University of Leeds as part of a Wellcome Trust funded program. My studies during my PhD were focused on the structural basis of ligand-receptor interactions in the P2X7 receptor, giving me a foundation in purinergic signalling and electrophysiology. I joined the Institute of Rheumatic and Musculoskeletal Medicine (LIRMM) at the University of Leeds as a postdoctoral research fellow in December 2018. My research forms part of the ImmunAID consortium (Immunome project consortium for AutoInflammatory Disorders), which is funded through the European Union’s Horizon 2020 research and innovation programme. My work package focuses specifically on inflammasome associated pathways involved in the pathogenesis of systemic autoinflammatory diseases, and is supervised by Prof. Michael McDermott and Dr. Sinisa Savic.
Systemic autoinflammatory disorders (SAIDs) consist of numerous rare disorders which are characterised by extensive inflammation, and are caused by the dysregulation of the innate immune system. The diagnosis of SAIDs is often hindered by the variation in symptoms and lack of dependable biomarkers, resulting in difficulty in effectively diagnosis and treatment. Our group have identified the NLRP3 inflammasome, and related pathways, as playing an integral role in the pathogenesis of these disorders. My research aims to assess the basis of inflammasome involvement in SAIDs, taking into account the dysregulation of inflammasome-related signalling and the interplay with other signalling pathways. We use an approach largely centred around the use of primary human samples, combined with techniques including in silico modelling, site-directed mutagenesis, protein expression and the Seahorse XF analyser for metabolic assays, with the ultimate goal of advancing pathogenesis-based SAID classification.
A detailed overview of the ImmunAID consortium can be found here: www.immunaid.eu/
- PhD: Molecular biology
- BSc (Hons): Neuroscience
- British Society for Immunology (BSI)
- Biochemical Society
Research groups and institutes
- Leeds Institute of Rheumatic and Musculoskeletal Medicine