Dr Lucinda Craggs

Dr Lucinda Craggs

Profile

I am a PDRA working in LICAMM within the research group of Dr Marc Bailey, working on his BHF-funded project to perform lineage tracing of vascular smooth muscle cells during the development of abdominal aortic aneurysms.

My past experience includes 18 months working as a Medical Writer, providing support to an International Medical Affairs team developing novel drugs and diagnostics in the field of neuroscience (Alzheimer's Disease and Spinal Muscular Atrophy). Prior to this I spent over 5 years working on mechanisms of cerebrovascular disease within the Institute of Ageing & Health, and the Institute of Neuroscience at Newcastle University.

Responsibilities

  • Tutor: Introduction to Medical Sciences MBChB Year 1
  • Tutor: Research, Evaluation and Special Studies (RESS) MBChB Year 1

Research interests

My current work focuses on understanding the pathophysiology of abdominal aortic aneurysms (AAA), with a specific focus on the fate of vascular smooth muscle cells within AAA. This BHF-funded project includes work on both preclinical models of AAA, with the aims of furthering the understanding of the pathways involved in the pathogenesis of AAA and to identify treatment strategies.

My past research experience includes five years investigating signalling pathways within VSMCs in various forms of vascular dementia, working on grants funded by the MRC and Alzheimer’s research UK at the University of Newcastle. My publications during this period include an investigation into the components of granular osmiophilic material (GOM) in a genetic form on early onset stroke associated with Notch3 mutations (cerebral autosomal dominant arteriopathy with subcortical infarcts, CADASIL). Much of my work at this time utilised brain tissue from the Newcastle brain tissue resource (NBTR) and included investigations into the notch signalling pathway in stroke and cerebral ischemia, and early onset inherited stroke disorders (PADMAL, Swedish hMID; HERNS).

I completed my BSc in Animal Science and PhD in Nutritional Science at the University of Nottingham. My Phd was an industry sponsored CASE-funded studentship between BBSRC and Pfizer where my thesis investigated the effects of vitamin D on skeletal muscle cell growth and function.

Qualifications

  • PhD Nutritional Science
  • BSc (Hons)

Professional memberships

  • Biochemical Society member

Student education

For the academic year 2018–2019 I am a tutor for the Introduction to Medical Sciences (IMS) MBChB, and lecture on CARD2010 BSc Cardiovascular Medicine (Cardiovascular response to stress), ARCS2120 Biology (Cell structure, function and cycle).

Research groups and institutes

  • Leeds Institute of Cardiovascular and Metabolic Medicine