Dr Vincenza Caolo

Dr Vincenza Caolo

Profile

I graduated in Molecular Biology at the University of Bologna (Italy) before starting my PhD study in Vascular Biology at Maastricht University (the Netherlands) and postdoctoral training at Katholieke Universiteit (KU) Leuven (Belgium).

I am currently a postdoctoral researcher in the research group of Professor David Beech.

Research interests

My major research interest is to investigate the significance of ion channel Piezo1 during vascular remodelling. During development, vascular remodelling is a crucial process and it dependent on blood flow. The passage of fluid results in physical forces in the endothelium, i.e. shear stress, which initiates molecular signalling cascades inside the cells necessary for the vascular remodelling. Endothelial cells can sense shear stress force through proteins localized on their plasma membrane, which will translate these stimuli into changes in gene expression by a process known as mechanotransduction. Piezo1, an ion channel able to sense shear stress, has been recently identified and its ablation results in serious defects of vascular remodelling. Specifically my research efforts focus on identifying new molecular signalling pathways activated in endothelial cells downstream of Piezo1 and shear stress.

Qualifications

  • PhD in Vascular Biology (Maastricht University, the Netherlands)
  • MSc in Molecular Biology (Bologna University, Italy)

Research groups and institutes

  • Leeds Institute of Cardiovascular and Metabolic Medicine