Samuel Lara-Reyna

Samuel Lara-Reyna


I started by receiving medical training at the faculty of Medicine UJED, Mexico, in which I developed an interest in immunology. I obtained my Bachelor’s degree in Biology at the University of Texas at San Antonio, Highest Honours and International Distinction,
with a focus on immunology & microbiology. During my studies in Texas, I worked at Dr LeBaron’s laboratory of molecular biology.
I was awarded CONACyT scholarship in 2015 and moved to Birmingham, UK, in which I obtained my Master’s degree in Immunology and Immunotherapy at the University of Birmingham.
I gained insight into innate immunity at the Queen Elizabeth Hospital, in which I worked with Professor Andy Clark, within the Institute of inflammation and ageing, rheumatology research group.
After my studies at the University of Birmingham, I was awarded with the CONACyT/Leeds Graduate Fellowship to accomplish my doctoral studies in Medicine, at the University of Leeds.
I am currently working at a cystic fibrosis strategic research centre at the University of Leeds, St James's University Hospital, under the supervision of Dr Sinisa Savic, Professor Daniel Peckham, and Professor Michael McDermott.

Research interests

Cellular stress is one of the main physiological activators of the unfolded protein response (UPR) in eukaryotic cells. These cells are under constant environmental and metabolic challenge, which may activate evolutionarily conserved mechanisms, such as the UPR, to reconstitute intracellular homeostasis. When intracellular equilibrium cannot be achieved, either due to specific mutations in key regulatory proteins or the presence of chronic inflammation, the cells may reprogram both gene and protein expression in order to preserve the most essential cellular functions. Dysfunctional cellular metabolism has been shown to activate the UPR in a range of metabolic, inflammatory, and immune disorders. I am interested in the three main sensors of the UPR, namely IRE1, PERK, and ATF6, and how these are regulated in immune-related disorders. I have a specific interest in the impact and consequences of cellular stress in immune cells.


  • BSc
  • MSc

Research groups and institutes

  • Leeds Institute of Medical Research at St James's
  • Leeds Institute of Rheumatic and Musculoskeletal Medicine