Professor Andrew Clegg

Profile

I am Head of Ageing and Stroke Research at the University of Leeds and Honorary Consultant Geriatrician at Bradford Royal Infirmary. I am Director of the global Ageing Research Trialist (ART) collaborative, established to support individual participant data meta-analysis in ageing research, and Co-Director for Health Data Research UK (HDRUK) North. I lead a large portfolio of ageing-related research, with a focus on frailty as an especially problematic expression of multimorbidity in later life, and medicines optimisation. I hold research grants of around £44M as lead or co-investigator, including leadership of a research theme focused on improving care for older people with frailty in the NIHR Applied Research Collaboration, Yorkshire & Humber and a workstream within the NIHR Leeds Biomedical Research Centre (BRC) Musculoskeletal Theme. Research expertise spans clinical trials of interventions, prognostic modelling using routine data, applied epidemiology and evidence synthesis. I am PI for the Personalised Care Planning for Older People with Frailty (PROSPER) NIHR-funded Research Programme, the NIHR HTA-funded Home-based Exercise for Older People (HERO) trial and the Community Ageing Research 75+ study – a longitudinal ageing and frailty cohort designed using trial within cohort methods, with routine data linkage. I previously led the development, validation and national implementation of the multi award-winning and NICE Multimorbidity Guideline-recommended electronic frailty index (eFI) using data from around 1M UK patients contained in the ResearchOne and THIN primary care research databases, with major impact on UK health policy and selected as a 2022 National Medical Schools Council Impact Case Exemplar.

I am a current member of the MRC Ageing Research Steering Group, supporting development of future activities in ageing research. I am also co-lead for the NIHR National Ageing, Dementia and Frailty Priority Theme, supporting national implementation of prioritised interventions into routine practice, and co-investigator with the NIHR Policy Research Unit for Older People and Frailty. I am a current member of the NICE Falls Prevention Guideline Development Group. Previous roles include as member of the NICE Multimorbidity Guideline Development Group, NICE Delirium Guideline Development Group, and joint Centre for Perioperative Care & British Geriatrics Society guideline on Perioperative Care for Older People with Frailty.

Responsibilities

• Theme Lead, NIHR ARC Yorkshire & Humber
• Associate Director, HDRUK North

Research interests

• Health Data Research UK 2nd Quinquennium (HDRUK QQ2). Co-Director, HDRUK North. MRC/NIHR/Wellcome/ESRC/EPSRC/CSO/BHF/CRUK. £71,800,000. 04/2023 - 03/2028

• NIHR Leeds Biomedical Research Centre. Workstream co-lead, Musculoskeletal Theme. National Institute for Health Research. £19,800,000. 12/2022 - 11/2027

• Buchan I, Walker L, Clegg A, Mair F, Kullu C, Sperrin M, Relton S, van Staa T, Gabbay M, Ruddle R, Bollegala D, Maskell S, Shantsila E, Leeming G, Woodall A, Griffiths A. AIs for dynamic prescribing optimisation and care integration in multimorbidity (DynAIRx). National Institute for Health and Care Research AI for Multiple Long-term Conditions. £2,807,430. 09/2022 - 08/2025

• Brown L, Forster A, Antcliff D, Clegg A, Schofield P, Suleman A, Williams A. Pain in Older People with Frailty (POPPY) study. £483,650. National Institute for Health and Care Research HSDR programme. 04/2022 - 03/2025

• Murtagh F, Pearson M, Walker L, Cohen J, Hussain J, Farrin A, Ziegler L, Clegg A, Spilsbury K, Collinson M, Cundill B, Fraser L, O’Cathain A, Taylor P, Johnson M, McAleese J, Rowson L. The Yorkshire & Humber Palliative Care Research Network: Addressing Inequalities Across All Ages. National Institute for Health Research. £99,932. 01/2022 - 07/2023

• Goodwin V, Whitney J, Frost J, Crocker T, Hamilton F, del Din S, Lamb S, Lyndon H, Hulme C, Clegg A, Creator S, Sanders T, Bethel A, Morley N. Digital and Remote Enhancements for the Assessment and Management of Older People Living with Frailty (DREAM). National Institute for Health Research Programme Development Grant. £149,463. 01/2022 - 03/2023

• ActAsOne Innovation Hub. The Health Foundation. £474,668. 10/2021 - 09/2023

• McManus R, Barnes R, Ford G, Ghadia S, Williams M, Sheppard J, Tucker K, Hobbs R, de Lusignan S, Perera R, Clegg A, Mant J, Payne R, Clarke C. Structured medication reviews in multimorbidity. National Institute for Health Research Applied Research Collaboration (Multimorbidity National Priority). £461,508. 04/2021 - 09/2023

• Fylan B, Silcock J, Alldred D, Cheong VL, Tyndale-Biscoe S, Clegg A. Understanding and enhancing medicines management resilience in home-dwelling older people living with frailty (£156,336). National Institute for Health Research (Research for Patient Benefit). 01/2021 - 01/2023

• Pirmohamed M, Buchan I, Clegg A, Jones M, King G, Knight  J, Mason S, Rodgers S, van Staa T. Health Data Research UK North (HDRUK North). UKRI/NIHR/Wellcome. £3,400,000. 05/2020 - 04/2023

• Clegg A, Crocker T, Ensor J, Forster A, Gladman J, Riley R. Community-based complex interventions for older people, stratified by frailty: a systematic review and network meta-analysis. National Institute for Health Research (Health Technology Assessment). £297,463. 04/2019 - 09/2021

• Walters K, Clegg A, Goodman C, Marston L, Hopkins J, Cooper C, Logan P, Skelton D, Hunter R, Manthorpe J, Gardner B, Brennan V, Frost R, Avgerinou C. Clinical and cost-effectiveness of a personalised health promotion intervention enabling independence in older people with mild frailty (HomeHealth): a randomised controlled trial. National Institute for Health Research (Health Technology Assessment). £1,799,724. 10/2020 - 09/2023

• Clegg A, Bucknall M, Conroy S, Hulme C, Humphrey S, Nikolova S, Relton S, Richards S, Riha W, Riley R, Van Der Windt D, Walters K, West R. Development and evaluation of the electronic frailty index+ (eFI+) tool: integrated prognostic-decision modelling to target interventions for older people with moderate or severe frailty. National Institute for Health Research (Health Technology Assessment). £548,507. 10/2019 - 05/202

• Wright J, Bojke L, Clegg A, Foy R, Gilbody S, Lawton R, Mason S, McCooe M, Slater B, Weich S, Young T. National Institute for Health Research Applied Research Collaborative Yorkshire & Humber (NIHR ARCYH). £9,000,000. 10/2019 - 09/2024

• Nikolova S, Akbar A, Clegg A, Fry R, Hawkins R, Hillcoat-Nalletamby S, Hollinghurst J, Meads D, Rodgers S. What is the cost-effectiveness of home adaptations for older people? Dunhill Medical Trust. £82,035. 09/2019 - 09/2020

• Walsh B, Roderick P, Fraser S, Brailsford S, Clegg A, Barkham A, Patel H, Zhu S, Harris S, de Lusignan S. The dynamics of frailty in older people: modelling impact on health care demand and outcomes to inform service planning and commissioning. National Institute for Health Research (Health Services and Delivery Research). £824,928. 04/2019 - 12/2021

• Silman A, Clegg A, Strauss V, Prieto-Alhambra D, Gentry T. Identifying trajectories of frailty in elderly individuals. National Institute for Health Research (Research for Patient Benefit). £149,550. 04/2019 - 03/2021

• Ekers D, Gilbody S, McMillan D, Travis-Turner G, Clegg A, Coventry P, Dexter-Smith S, Ali S, Bosanquet K, Brown D, Hill A, Hewitt C, Lovell K, Gentry T, Chew-Graham C. Multimorbidity in Older Adults with Depression Study. NIHR PGfAR. £2,429,219. 10/2018 - 07/2024

• Clegg A, Young J, Bower P, Cundall B, Farrin A, Foster M, Foy R, Hartley S, Hawkins R, Holmes J, Hulme C, Humphrey S, Lawton R, Pendleton N, West R. Personalised care planning to improve quality of life for older people with frailty. NIHR PGfAR. £2,748,666. 10/2017 - 02/2023

• Rodgers S, Kerridge D, Clegg A, Lyons R, Williams N. Safe in my own home? Investigating the impact of community home modification services on hospital utilisation for fall injuries: a controlled longitudinal study using data linkage. Health & Care Research Wales. £241,749. 10/2017 - 12/2019

• Clegg A, Clarke D, Cundill B, Farrin A, Forster A, Goodwin V, Hartley S, Hulme C, Wright P, Young J. Individually randomised controlled multicentre trial to determine the clinical and cost-effectiveness of a home-based exercise intervention for older people with frailty as extended rehabilitation following acute illness or injury, including embedded process evaluation. NIHR HTA. £2,038,930, 03/2017 - 06/2021

• de Biase S, Snee E, Haddad R, Clegg A, Volpe J, Slater B. Supported self-management for older people with frailty. Health Foundation. £75,000, 01/2017 - 06/2018 \n Wright J, Parslow R, Hide W, Newman C, Pickett K, Clegg A. Connected Yorkshire: building a digital community across Yorkshire and Humber. Office of Life Sciences. £4M, 2016 - 2019

• Young J, Clegg A, Nolan M, Mountain G, Noble B, Teale E, Parker S, Hawkins R, Spilsbury K, Hanratty B, Short O, Astell A, Young T. Primary care-based management of frailty in older people. NIHR CLAHRC, £999,868, Jan 2014-Dec 2018.

• Clegg A, Young J. Development and evaluation of the home-based older people's exercise (HOPE) programme. Dunhill Medical Trust & Royal College of Physicians, £106,953 Oct 2009-Sept 2011.

Qualifications

• MD (Res) UCL 2012
• MRCP (Lon) 2006
• MBBS (Hons) UCL 2003
• BsC (Pharmacology) UCL 2000

Professional memberships

• RCP London

Student education

• Lead, NIHR ARC Yorkshire & Humber Later Life Doctoral Research Network
• Lead, White Rose ‘Bouncing Back’ PhD Network
• Lead, NIHR ACF Programme in Geriatric Medicine
• Lead, and co-supervisor for PhD and MD students
• Clinical Lead, 5th Year Medical Student Elderly Medicine Placement
• ESREP Tutor

Research groups and institutes

• Leeds Institute of Health Sciences
• Frailty and elderly care
• Successful ageing

Current postgraduate researchers

• Ragy Tadrous