Jennifer Kirkham

Jennifer Kirkham

Profile

Primary research theme: Biomineralisation

Chair in Oral Biology, University of Leeds (1999)\n PhD in Oral Biology, University of Leeds (1985)

BSc (Hons), University of Coventry (1980)

All appointments held at the University of Leeds

Interim Dean of the School of Dentistry (current since 2017)

EPSRC Translational Professor (current since 2010)

Pro-Dean for Research and Innovation, Faculty of Medicine & Health (2009-2014)

Head of Oral Biology (1999 - ) \n Director of Research, Leeds School of Dentistry (2005-2009)

Reader in Oral Biology (1997-1999) \n Senior Lecturer in Oral Biology (1995-1997)

Lecturer in Oral Biology (1985-1994)

Jennifer Kirkham has >30 year’s experience in Dental Research, with particular emphasis on the role of extracellular matrices (ECM) in the control of crystal deposition and growth in the skeletal tissues, including the development of biomimetic materials. Her group’s work in Biomineralisation was rated “world leading” by the RAE2008 sub-panel. She also leads the stem cell research theme as co-applicant in the £11.2m Wellcome-EPSRC Centre of Excellence in Medical Engineering and is one of six Translational Professors in the £7.3m EPSRC-TSB Innovation Centre for Excellence in Medical Technologies. She secured funding totalling >£1m from the Wellcome Trust to establish the UK’s first ever dedicated state-of-the-art clinical translational research facility in Dentistry. She has also successfully supervised more than 25 PhD students to completion including Clinical Academics in Dentistry and Medicine.

She has published more than 150 research papers, holds/ has held grants from all of the major UK Research Councils and the EU and has a wide portfolio of awards from Industrial sponsors. Awards over the last 5y total >£26.5m. She is holds patents in the UK, Europe and the USA. Internationally, she holds an affiliated Professorship at the Forsyth Center for Dental Research, Boston, USA and is an Honorary Professor at the Dental School, Nanjing University, PR China.

Jennifer Kirkham is a former President of the IADR Mineralised Tissue Group. In the UK, she was a member of the HEFCE sub-Panel 10 (Dentistry) for the Research Assessment Exercise (RAE) and is a former president of the British Mineralised Tissue Group of the British Society for Dental Research. In 2009, she was appointed Pro-Dean for Research and Innovation for the Faculty of Medicine and Health.Oral Biology

Research Areas

Mechanisms for controlling mineral deposition and growth in the skeletal tissues

Phenotype-genotype relationships in inherited defects of the dentition\n Molecular basis of inherited dental disease\n Biomimetic strategies for skeletal tissue regeneration and repair\n Hard tissue engineering, including use of self-assembling peptide systems

Use of adult stem cells in regenerative medicine including methods for non-invasive phenotyping

Funding

EPSRC IKC POC Tranche 1 (PI) Self-assembling peptides £50k

EPSRC IKC POC Tranche 2 (PI) Self-assembling peptides £49k

Wellcome Trust (Co-I) 2013-18 Atomic force microscope for cross-faculty biomedical research at the University of Leeds £343k

IKC-Credentis ag (PI) 2012-14 Filling without drilling £1m

Wellcome Trust project grant (PI) 2011-14 AI as a paradigm for biomineralisation £495k

Credentis ag (Co-I) 2010-11 Funding for proof-of clinical concept trial £50k

Wellcome Trust (PI) 2010-15 Establishment of a Clinical and Translational Research Facility at Leeds Dental Institute £1.6m

EPSRC (Co-I) 2009-14 Establishment of an Innovation & Knowledge Centre (IKC) in Regenerative Therapies and Devices £5.2m

Wellcome Trust (Co-I) 2009-14 Engineering Solutions for an Ageing Population with Musculoskeletal & Cardiovascular Disease; 50 more years after 50 £11.2m

Wellcome Trust project grant (Co-I) 2008-11 Genetic dissection of biomineralisation defects and links with retinal degeneration £185k \n Wellcome Trust Programme Funding (PI) 2005-11 Odontogenesis: A paradigm for mammalian biomineralisation £1.2m

Access to central facilities: 2011 7 days on REFSANS FRM II, Germany; 2010 3 days and 2008 4 days ILL, Grenoble, France \n IKC-Credentis ag (PI) 2012-14 Filling without drilling £1m \n Wellcome Trust project grant (PI) 2011-14 AI as a paradigm for biomineralisation £495k

Credentis ag (Co-I) 2010-11 Funding for proof-of clinical concept trial £50k

Wellcome Trust (PI) 2010-15 Establishment of a Clinical and Translational Research Facility at Leeds Dental Institute £1.6m

EPSRC (Co-I) 2009-14 Establishment of an Innovation & Knowledge Centre (IKC) in Regenerative Therapies and Devices £5.2m \n Wellcome Trust (Co-I) 2009-14 Engineering Solutions for an Ageing Population with Musculoskeletal & Cardiovascular Disease; 50 more years after 50 £11.2m

Wellcome Trust project grant (Co-I) 2008-11 Genetic dissection of biomineralisation defects and links with retinal degeneration £185k

Wellcome Trust Programme Funding (PI) 2005-11 Odontogenesis: A paradigm for mammalian biomineralisation £1.2m \n Access to central facilities: 2011 7 days on REFSANS FRM II, Germany; 2010 3 days and 2008 4 days ILL, Grenoble, France

Current Postgraduate Research Degree Supervision

Kingswell N (PhD) The role of extracellular matrix proteins in tooth enamel \n Mitchell A (PhD) Raman spectroscopy in the non-invasive phenotyping of human dental pulp stem cells (DPSCs) - evaluation of suitable cell culture parameters \n Russell H (PhD) Tissue engineering in dentistry: engineering a new dental pulp

Key Research Collaborations

In the University of Leeds

WELMEC Engineering Solutions for an Ageing Population with Musculoskeletal & Cardiovascular Disease\n Innovation & Knowledge Centre (IKC) in Medical Technologies\n EPSRC DTC in Tissue Engineering and Regenerative Medicine

Self-Organising Molecular Systems (SOMS) Group, Department Chemistry - Use of self-assembling peptide technology in regenerative medicine

Leeds Institute of Molecular Medicine - Understanding biomineralisation through identification of dental gene defects

Leeds Musculoskeletal Biomedical Research Unit (LMBRU)

In the UK

University of Manchester - Relating phenotype to the underlying genetic lesion in inherited dental abnormalities

Queen Mary and Westfield College - Use of neutron scattering to interrogate mineral-matrix interactions

Avacta plc, York - Use of spectroscopy in non-invasive stem cell phenotyping\n Xiros plc, Leeds - Development of tissue engineering tools

International

University of Pennsylvania, USA - Convergent transcription in the nested gene

University of Michigan - Formal collaboration agreement between Leeds Dental Institute & the Dental School at Ann Arbor\n University of Nanjing, PR China - Formal collaboration agreement\n Credentis ag - Development of peptide solutions for dental repair

Prizes and Awards

Charles Tome Lecture Prize, Royal College of Surgeons, Faculty of Dentistry 2012

Teaching Areas

Oral Biology, Oral biochemistry and saliva, oral and dental disease, connective tissue biochemistry, skeletal tissue engineering

Professional Activities

Affiliate Professor at the Forsyth Institute, Boston, MA, USA•Reviewer for EPSRC, MRC, BBSRC and Wellcome Trust

Reviewer for Research Councils in Israel, Canada and US (NIH) Health service R&D Ireland\n Honorary Professor, School of Medicine, University of Nanjing, PR China

Chair, Tooth Enamel IX, International Workshop on Tooth Enamel

Keynote speaker at World Universities Network Symposium in Oral Health Science, Leeds 2011

Chair and speaker at Enamel 8 Conference, Starved Rock, USA 2011

Visiting Professor, University of San Jose, Costa Rica 2011

Keynote speaker at International Association of Dental Research, Barcelona, Spain 2010

Scientific Advisory Board and Organising Committee member, Enamel 8, Illinois, USA 2009-11

Scientific Advisory Board member, International Conference on the Chemistry and Biology of Mineralised Tissues 2009

Invited speaker, Mineralised Tissue Symposium, BSDR, Glasgow 2009

Invited speaker and Chair, Medical Innovation Forum, Harrogate 2009

HEFCE Sub-panel member, Dentistry RAE 2008

<h4>Postgraduate research opportunities</h4> <p>We welcome enquiries from motivated and qualified applicants from all around the world who are interested in PhD study. Our <a href="https://medicinehealth.leeds.ac.uk/research-opportunities">research opportunities</a> allow you to search for projects and scholarships.</p>